Helical peptaibol mimics are better ionophores when racemic than when enantiopure

Sarah J. Pike; Jennifer E. Jones; James Raftery; Jonathan Clayden; Simon J. Webb

doi:10.1039/c5ob01652e

Helical peptaibol mimics are better ionophores when racemic than when enantiopure

Sarah J. Pike, Jennifer E. Jones, James Raftery, Jonathan Clayden^*, Simon J. Webb

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

7 Citations (Scopus)

Abstract

Helical peptide foldamers rich in α-aminoisobutyric acid (Aib) act as peptaibol-mimicking ionophores in the phospholipid bilayers of artificial vesicles. Racemic samples of these foldamers are more active than their enantiopure counterparts, which was attributed to differing propensities to form aggregates with crystal-like features in the bilayer.

Original language	English
Pages (from-to)	9580-9584
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	13
Issue number	37
DOIs	https://doi.org/10.1039/c5ob01652e
Publication status	Published - 21 Aug 2015

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title = "Helical peptaibol mimics are better ionophores when racemic than when enantiopure",

abstract = "Helical peptide foldamers rich in α-aminoisobutyric acid (Aib) act as peptaibol-mimicking ionophores in the phospholipid bilayers of artificial vesicles. Racemic samples of these foldamers are more active than their enantiopure counterparts, which was attributed to differing propensities to form aggregates with crystal-like features in the bilayer.",

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AU - Pike, Sarah J.

AU - Jones, Jennifer E.

AU - Raftery, James

AU - Clayden, Jonathan

AU - Webb, Simon J.

PY - 2015/8/21

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N2 - Helical peptide foldamers rich in α-aminoisobutyric acid (Aib) act as peptaibol-mimicking ionophores in the phospholipid bilayers of artificial vesicles. Racemic samples of these foldamers are more active than their enantiopure counterparts, which was attributed to differing propensities to form aggregates with crystal-like features in the bilayer.

AB - Helical peptide foldamers rich in α-aminoisobutyric acid (Aib) act as peptaibol-mimicking ionophores in the phospholipid bilayers of artificial vesicles. Racemic samples of these foldamers are more active than their enantiopure counterparts, which was attributed to differing propensities to form aggregates with crystal-like features in the bilayer.

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U2 - 10.1039/c5ob01652e

DO - 10.1039/c5ob01652e

M3 - Article (Academic Journal)

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AN - SCOPUS:84941901076

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SP - 9580

EP - 9584

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

IS - 37

ER -

Helical peptaibol mimics are better ionophores when racemic than when enantiopure

Abstract

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