Helical peptaibol mimics are better ionophores when racemic than when enantiopure

Sarah J. Pike, Jennifer E. Jones, James Raftery, Jonathan Clayden*, Simon J. Webb

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Abstract

Helical peptide foldamers rich in α-aminoisobutyric acid (Aib) act as peptaibol-mimicking ionophores in the phospholipid bilayers of artificial vesicles. Racemic samples of these foldamers are more active than their enantiopure counterparts, which was attributed to differing propensities to form aggregates with crystal-like features in the bilayer.

Original languageEnglish
Pages (from-to)9580-9584
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume13
Issue number37
DOIs
Publication statusPublished - 21 Aug 2015

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