Helical peptaibol mimics are better ionophores when racemic than when enantiopure

Sarah J. Pike; Jennifer E. Jones; James Raftery; Jonathan Clayden; Simon J. Webb

doi:10.1039/c5ob01652e

Helical peptaibol mimics are better ionophores when racemic than when enantiopure

Sarah J. Pike, Jennifer E. Jones, James Raftery, Jonathan Clayden^*, Simon J. Webb

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal)

5 Citations (Scopus)

Abstract

Helical peptide foldamers rich in α-aminoisobutyric acid (Aib) act as peptaibol-mimicking ionophores in the phospholipid bilayers of artificial vesicles. Racemic samples of these foldamers are more active than their enantiopure counterparts, which was attributed to differing propensities to form aggregates with crystal-like features in the bilayer.

Original language	English
Pages (from-to)	9580-9584
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	13
Issue number	37
DOIs	https://doi.org/10.1039/c5ob01652e
Publication status	Published - 21 Aug 2015

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10.1039/c5ob01652e

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Pike, S. J., Jones, J. E., Raftery, J., Clayden, J., & Webb, S. J. (2015). Helical peptaibol mimics are better ionophores when racemic than when enantiopure. Organic and Biomolecular Chemistry, 13(37), 9580-9584. https://doi.org/10.1039/c5ob01652e

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