Helminths and microbes within the vertebrate gut: not all studies are created equal

Alba Cortés, Laura E. Peachey, Timothy P. Jenkins, Riccardo Scotti, Cinzia Cantacessi*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

27 Citations (Scopus)


The multifaceted interactions occurring between gastrointestinal (GI) parasitic helminths and the host gut microbiota are emerging as a key area of study within the broader research domain of host-pathogen relationships. Over the past few years, a wealth of investigations has demonstrated that GI helminths interact with the host gut flora, and that such interactions result in modifications of the host immune and metabolic statuses. Nevertheless, whilst selected changes in gut microbial composition are consistently observed in response to GI helminth infections across several host-parasite systems, research in this area to date is largely characterised by inconsistent findings. These discrepancies are particularly evident when data from studies of GI helminth-microbiota interactions conducted in humans from parasite-endemic regions are compared. In this review, we provide an overview of the main sources of variance that affect investigations on helminth-gut microbiota interactions in humans, and propose a series of methodological approaches that, whilst accounting for the inevitable constraints of fieldwork, are aimed at minimising confounding factors and draw biologically meaningful interpretations from highly variable datasets.
Original languageEnglish
Pages (from-to)1371-1378
Number of pages8
Issue number11
Early online date31 Jul 2019
Publication statusPublished - 1 Sept 2019


  • anthelmintics
  • bacterial 16S rRNA sequencing
  • confounding factors
  • Helminth-microbiota interactions
  • soil-transmitted helminths


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