Abstract
Phenyl stabilised chiral sulfur ylides react with five-membered-ring hemiaminals to give functionalised pyrrolidines directly with high enandoselectivity. The reaction can be diverted to give piperidines instead by isolation of the intermediate epoxide and treatment with TMSOTf.
| Original language | English |
|---|---|
| Pages (from-to) | 2156-2158 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - 28 May 2006 |
Research Groups and Themes
- Organic & Biological
Keywords
- THROMBOXANE RECEPTOR ANTAGONIST
- EPOXIDE OPENINGS
- (+/-)-(5Z)-7-<3-ENDO-<(PHENYLSULFONYL)AMINO>BICYCLO<2.2.1>HEPT-2-EXO-YL>HEPTENO ACID
- STEREOSELECTIVE-SYNTHESIS
- TETRAHYDROPYRAN SYSTEMS
- DERIVATIVES
- 6-ENDO
- 5-EXO
- STEREOISOMERS
- ACTIVATION
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