Hemodynamic Features in Stenosed Coronary Arteries: CFD Analysis Based on Histological Images

Mahsa Dabagh*, Wakako Takabe, Payman Jalali, Stephen White, Hanjoong Jo

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

5 Citations (Scopus)

Abstract

Histological images from the longitudinal section of four diseased coronary arteries were used, for the first time, to study the pulsatile blood flow distribution within the lumen of the arteries by means of computational fluid dynamics (CFD). Results indicate a strong dependence of the hemodynamics on the morphology of atherosclerotic lesion. Distinctive flow patterns appear in different stenosed regions corresponding to the specific geometry of any artery. Results show that the stenosis affects the wall shear stress (WSS) locally along the diseased arterial wall as well as other adjacent walls. The maximum magnitude of WSS is observed in the throat of stenosis. Moreover, high oscillatory shear index (OSI) is observed along the stenosed wall and the high curvature regions. The present study is capable of providing information on the shear environment in the longitudinal section of the diseased coronary arteries, based on the models created from histological images. The computational method may be used as an effective way to predict plaque forming regions in healthy arterial walls.

Original languageEnglish
Article number715407
Number of pages11
JournalIAENG International Journal of Applied Mathematics
DOIs
Publication statusPublished - 2013

Keywords

  • HUMAN AORTIC-ARCH
  • BLOOD-FLOW
  • SIMULATION
  • TRANSPORT
  • MODEL
  • ATHEROSCLEROSIS
  • ULTRASOUND

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