Hepatitis B: future curative strategies

Antonio Bertoletti, Laura Rivino

Research output: Contribution to journalReview article (Academic Journal)peer-review

Abstract

PURPOSE OF REVIEW: Hepatitis B virus (HBV) causes a large proportion of chronic liver disease worldwide. The limited efficiency of current treatments based on the use of nucleotide/nucleoside analogues or interferon-alpha requires the development of new therapeutic tools for the treatment of chronic HBV. We summarize the most recent therapeutic strategies designed to directly target HBV-infected hepatocytes or to restore antiviral immunity during chronic HBV infection.

RECENT FINDINGS: Novel therapies directly target HBV-infected hepatocytes by inducing covalently closed circular DNA degradation or by inhibiting HBV entry or the expression of viral proteins. In addition, immunotherapeutic approaches may boost HBV-specific T-cell responses or stimulate the intrahepatic innate response.

SUMMARY: These new therapeutic approaches have mainly been tested in animal models. In humans, therapeutic strategies could be tailored to different chronic HBV patients in relation to their clinical and virological disease profile.

Original languageEnglish
Pages (from-to)528-34
Number of pages7
JournalCurrent Opinion in Infectious Diseases
Volume27
Issue number6
DOIs
Publication statusPublished - Dec 2014

Keywords

  • Adaptive Immunity/drug effects
  • Antiviral Agents/administration & dosage
  • Hepatitis B virus/drug effects
  • Hepatitis B, Chronic/drug therapy
  • Hepatocytes/drug effects
  • Humans
  • Immunity, Innate/drug effects
  • Interferon alpha-2
  • Interferon-alpha/administration & dosage
  • Liver/immunology
  • Recombinant Proteins/administration & dosage
  • Treatment Outcome
  • Viral Load
  • Virus Replication/immunology

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