HEPCARE EUROPE: A Case study of a Service Innovation Project Aiming at Improving the Elimination of HCV in Vulnerable Populations in Four European Cities

Gordon Avramovic, Maeve Reilly, Walter Cullen, Juan Macias, Geoff McCombe, Tina McHugh, Christiana Oprea, Alistair Story, Julian Surey, Caroline A Sabin, Sandra Bivegete, Peter T Vickerman, Josephine G Walker, Zoe D Ward, John S. Lambert*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

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Abstract

Objectives
Hepatitis C Virus (HCV) is an important cause of chronic liver disease. Among at-risk populations, access to diagnosis and treatment is challenging. We describe an integrated model of care, Hepcare Europe, developed to address this challenge.
Methods
Using a case-study approach, we describe the cascade of care outcomes at all sites. Costing analyses estimated the cost per person screened and linked to care.
Results
A total of 2608 participants were recruited across 218 clinical sites. HCV antibody test results were obtained for 2568(98.5%), 1074(41.8%) were antibody-positive, 687(60.5%) tested positive for HCV-RNA, 650(60.5%) were linked to care and 319(43.5%) started treatment. 196(61.4%) of treatment initiates achieved a Sustained Viral Response (SVR) at dataset closure, 108(33.9%) were still on treatment, 8(2.7%) defaulted from treatment, and 7(2.6%) had a virologic failure or died. The cost per person screened varied from Є194 to Є635, while cost per person linked to care varied from Є364 to Є2035.
Conclusions
Hepcare enhanced access to HCV treatment and cure, costs were affordable in all settings, offering a framework for scale-up and reproducibility.
Original languageEnglish
JournalInternational Journal of Infectious Diseases
DOIs
Publication statusAccepted/In press - 22 Sep 2020

Keywords

  • Hepatitis C
  • Vulnerable populations
  • people who inject drugs (PWID)
  • integrated HCV care
  • cascade of caresystem of care
  • HCV elimination

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