HER2 testing of gastro-oesophageal adenocarcinoma: a commentary and guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Committee

Newton A.C.S. Wong*, Fernanda Amary, Rachel Butler, Richard Byers, David Gonzalez, Harry R. Haynes, Mohammad Ilyas, Manuel Salto-Tellez, Philippe Taniere

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

6 Citations (Scopus)
336 Downloads (Pure)

Abstract

The use of biologics targeted to the human epidermal growth factor receptor 2 (HER2) protein is the latest addition to the armamentarium used to fight advanced gastric or gastro-oesophageal junction adenocarcinoma. The decision to treat with the biologic trastuzumab is completely dependent on HER2 testing of tumour tissue. In 2017, the College of American Pathologists, American Society for Clinical Pathology and the American Society of Clinical Oncology jointly published guidelines for HER2 testing and clinical decision making in gastro-oesophageal adenocarcinoma. The Association of Clinical Pathologists Molecular Pathology and Diagnostics Committee has issued the following document as a commentary of these guidelines and, in parallel, to provide guidance on HER2 testing in National Health Service pathology departments within the UK. This guidance covers issues related to case selection, preanalytical aspects, analysis and interpretation of such HER2 testing.

Original languageEnglish
Pages (from-to)388-394
Number of pages7
JournalJournal of Clinical Pathology
Volume71
Issue number5
Early online date8 Feb 2018
DOIs
Publication statusPublished - 1 May 2018

Keywords

  • adenocarcinoma stomach
  • guidance
  • HER2
  • immunohistochemistry
  • in-situ hybridisation
  • oesophagus

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