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Herpes simplex virus type-1 counteracts tetherin restriction via its virion host shutoff activity. HSV-1 vhs is a tetherin antagonist

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Herpes simplex virus type-1 counteracts tetherin restriction via its virion host shutoff activity. HSV-1 vhs is a tetherin antagonist. / Zenner, Helen; Mauricio, Rui; Banting, George; Crump, Colin.

In: Journal of Virology, 2013.

Research output: Contribution to journalArticle

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Zenner, H., Mauricio, R., Banting, G., & Crump, C. (Accepted/In press). Herpes simplex virus type-1 counteracts tetherin restriction via its virion host shutoff activity. HSV-1 vhs is a tetherin antagonist. Journal of Virology.

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Zenner, Helen ; Mauricio, Rui ; Banting, George ; Crump, Colin. / Herpes simplex virus type-1 counteracts tetherin restriction via its virion host shutoff activity. HSV-1 vhs is a tetherin antagonist. In: Journal of Virology. 2013.

Bibtex

@article{2061f991261b4795a8bc11e81fe27e5f,
title = "Herpes simplex virus type-1 counteracts tetherin restriction via its virion host shutoff activity.: HSV-1 vhs is a tetherin antagonist",
abstract = "The interferon inducible membrane protein tetherin (Bst-2/CD317) is an antiviral factor that inhibits enveloped virus release by cross-linking newly formed virus particles to the producing cell. The majority of viruses that are sensitive to tetherin restriction appear to be those that acquire their envelope at the plasma membrane, although many viruses, including herpesviruses, envelope at intracellular membranes and the effect of tetherin on such viruses has been less well studied. We have investigated the tetherin sensitivity and possible countermeasures of herpes simplex virus type-1 (HSV-1). We find that over-expression of tetherin inhibits HSV-1 release and that HSV-1 efficiently depletes tetherin from infected cells. We further show that the virion host shutoff (vhs) protein is important for depletion of tetherin mRNA and protein, and that removal of tetherin compensates for defects in replication and release of a vhs-null virus. Vhs is known to be important for HSV-1 to evade the innate immune response in vivo. Taken together, our data suggests that tetherin has antiviral activity towards HSV-1 and the removal of tetherin by vhs is important for the efficient replication and dissemination of HSV-1.",
keywords = "Herpesvirus, tetherin, HSV-1, virion host shutoff, virus release",
author = "Helen Zenner and Rui Mauricio and George Banting and Colin Crump",
year = "2013",
language = "English",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Herpes simplex virus type-1 counteracts tetherin restriction via its virion host shutoff activity.

T2 - HSV-1 vhs is a tetherin antagonist

AU - Zenner, Helen

AU - Mauricio, Rui

AU - Banting, George

AU - Crump, Colin

PY - 2013

Y1 - 2013

N2 - The interferon inducible membrane protein tetherin (Bst-2/CD317) is an antiviral factor that inhibits enveloped virus release by cross-linking newly formed virus particles to the producing cell. The majority of viruses that are sensitive to tetherin restriction appear to be those that acquire their envelope at the plasma membrane, although many viruses, including herpesviruses, envelope at intracellular membranes and the effect of tetherin on such viruses has been less well studied. We have investigated the tetherin sensitivity and possible countermeasures of herpes simplex virus type-1 (HSV-1). We find that over-expression of tetherin inhibits HSV-1 release and that HSV-1 efficiently depletes tetherin from infected cells. We further show that the virion host shutoff (vhs) protein is important for depletion of tetherin mRNA and protein, and that removal of tetherin compensates for defects in replication and release of a vhs-null virus. Vhs is known to be important for HSV-1 to evade the innate immune response in vivo. Taken together, our data suggests that tetherin has antiviral activity towards HSV-1 and the removal of tetherin by vhs is important for the efficient replication and dissemination of HSV-1.

AB - The interferon inducible membrane protein tetherin (Bst-2/CD317) is an antiviral factor that inhibits enveloped virus release by cross-linking newly formed virus particles to the producing cell. The majority of viruses that are sensitive to tetherin restriction appear to be those that acquire their envelope at the plasma membrane, although many viruses, including herpesviruses, envelope at intracellular membranes and the effect of tetherin on such viruses has been less well studied. We have investigated the tetherin sensitivity and possible countermeasures of herpes simplex virus type-1 (HSV-1). We find that over-expression of tetherin inhibits HSV-1 release and that HSV-1 efficiently depletes tetherin from infected cells. We further show that the virion host shutoff (vhs) protein is important for depletion of tetherin mRNA and protein, and that removal of tetherin compensates for defects in replication and release of a vhs-null virus. Vhs is known to be important for HSV-1 to evade the innate immune response in vivo. Taken together, our data suggests that tetherin has antiviral activity towards HSV-1 and the removal of tetherin by vhs is important for the efficient replication and dissemination of HSV-1.

KW - Herpesvirus

KW - tetherin

KW - HSV-1

KW - virion host shutoff

KW - virus release

M3 - Article

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

ER -