Abstract
We report that an HSV-2 UL14 protein expressing cell line (14/HEp-2) was more resistant to apoptosis induced by osmotic shock and certain drugs than its parental cell line. Furthermore, HSV-1 UL14 protein deletion virus (UL14D) showed weaker inhibition of apoptosis compared to the rescued virus UL14R. The protein's anti-apoptotic function may derive from its heat shock protein-like properties.
Original language | English |
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Pages (from-to) | 685-9 |
Number of pages | 5 |
Journal | Microbiology and Immunology |
Volume | 47 |
Issue number | 9 |
Publication status | Published - 2003 |
Keywords
- Apoptosis
- Camptothecin
- Caspase 3
- Caspases
- Cell Line, Tumor
- Epithelial Cells
- Etoposide
- Herpesvirus 2, Human
- Humans
- Osmotic Pressure
- Poly(ADP-ribose) Polymerases
- Staurosporine
- Viral Proteins
- Journal Article
- Research Support, Non-U.S. Gov't