Herpes simplex virus UL14 protein blocks apoptosis

Yohei Yamauchi, Tohru Daikoku, Fumi Goshima, Yukihiro Nishiyama

Research output: Contribution to journalArticle (Academic Journal)peer-review

34 Citations (Scopus)

Abstract

We report that an HSV-2 UL14 protein expressing cell line (14/HEp-2) was more resistant to apoptosis induced by osmotic shock and certain drugs than its parental cell line. Furthermore, HSV-1 UL14 protein deletion virus (UL14D) showed weaker inhibition of apoptosis compared to the rescued virus UL14R. The protein's anti-apoptotic function may derive from its heat shock protein-like properties.

Original languageEnglish
Pages (from-to)685-9
Number of pages5
JournalMicrobiology and Immunology
Volume47
Issue number9
Publication statusPublished - 2003

Keywords

  • Apoptosis
  • Camptothecin
  • Caspase 3
  • Caspases
  • Cell Line, Tumor
  • Epithelial Cells
  • Etoposide
  • Herpesvirus 2, Human
  • Humans
  • Osmotic Pressure
  • Poly(ADP-ribose) Polymerases
  • Staurosporine
  • Viral Proteins
  • Journal Article
  • Research Support, Non-U.S. Gov't

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