Herpes simplex virus UL14 protein blocks apoptosis

Yohei Yamauchi; Tohru Daikoku; Fumi Goshima; Yukihiro Nishiyama

Herpes simplex virus UL14 protein blocks apoptosis

Yohei Yamauchi, Tohru Daikoku, Fumi Goshima, Yukihiro Nishiyama

School of Cellular and Molecular Medicine

Research output: Contribution to journal › Article (Academic Journal) › peer-review

34 Citations (Scopus)

Abstract

We report that an HSV-2 UL14 protein expressing cell line (14/HEp-2) was more resistant to apoptosis induced by osmotic shock and certain drugs than its parental cell line. Furthermore, HSV-1 UL14 protein deletion virus (UL14D) showed weaker inhibition of apoptosis compared to the rescued virus UL14R. The protein's anti-apoptotic function may derive from its heat shock protein-like properties.

Original language	English
Pages (from-to)	685-9
Number of pages	5
Journal	Microbiology and Immunology
Volume	47
Issue number	9
Publication status	Published - 2003

Keywords

Apoptosis
Camptothecin
Caspase 3
Caspases
Cell Line, Tumor
Epithelial Cells
Etoposide
Herpesvirus 2, Human
Humans
Osmotic Pressure
Poly(ADP-ribose) Polymerases
Staurosporine
Viral Proteins
Journal Article
Research Support, Non-U.S. Gov't

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title = "Herpes simplex virus UL14 protein blocks apoptosis",

abstract = "We report that an HSV-2 UL14 protein expressing cell line (14/HEp-2) was more resistant to apoptosis induced by osmotic shock and certain drugs than its parental cell line. Furthermore, HSV-1 UL14 protein deletion virus (UL14D) showed weaker inhibition of apoptosis compared to the rescued virus UL14R. The protein's anti-apoptotic function may derive from its heat shock protein-like properties.",

keywords = "Apoptosis, Camptothecin, Caspase 3, Caspases, Cell Line, Tumor, Epithelial Cells, Etoposide, Herpesvirus 2, Human, Humans, Osmotic Pressure, Poly(ADP-ribose) Polymerases, Staurosporine, Viral Proteins, Journal Article, Research Support, Non-U.S. Gov't",

author = "Yohei Yamauchi and Tohru Daikoku and Fumi Goshima and Yukihiro Nishiyama",

year = "2003",

language = "English",

volume = "47",

pages = "685--9",

journal = "Microbiology and Immunology",

number = "9",

}

TY - JOUR

T1 - Herpes simplex virus UL14 protein blocks apoptosis

AU - Yamauchi, Yohei

AU - Daikoku, Tohru

AU - Goshima, Fumi

AU - Nishiyama, Yukihiro

PY - 2003

Y1 - 2003

N2 - We report that an HSV-2 UL14 protein expressing cell line (14/HEp-2) was more resistant to apoptosis induced by osmotic shock and certain drugs than its parental cell line. Furthermore, HSV-1 UL14 protein deletion virus (UL14D) showed weaker inhibition of apoptosis compared to the rescued virus UL14R. The protein's anti-apoptotic function may derive from its heat shock protein-like properties.

AB - We report that an HSV-2 UL14 protein expressing cell line (14/HEp-2) was more resistant to apoptosis induced by osmotic shock and certain drugs than its parental cell line. Furthermore, HSV-1 UL14 protein deletion virus (UL14D) showed weaker inhibition of apoptosis compared to the rescued virus UL14R. The protein's anti-apoptotic function may derive from its heat shock protein-like properties.

KW - Apoptosis

KW - Camptothecin

KW - Caspase 3

KW - Caspases

KW - Cell Line, Tumor

KW - Epithelial Cells

KW - Etoposide

KW - Herpesvirus 2, Human

KW - Humans

KW - Osmotic Pressure

KW - Poly(ADP-ribose) Polymerases

KW - Staurosporine

KW - Viral Proteins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Article (Academic Journal)

C2 - 14584616

VL - 47

SP - 685

EP - 689

JO - Microbiology and Immunology

JF - Microbiology and Immunology

IS - 9

ER -

Herpes simplex virus UL14 protein blocks apoptosis

Abstract

Keywords

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