Heterogeneity of Purkinje cell simple spike-complex spike interactions: zebrin- and non-zebrin-related variations

Tianyu Tang, Jianqiang Xiao, Colleen Suh, Amelia Burroughs, Nadia Cerminara, Linjia Jia, Sarah Marshall, Andrew Wise, Richard Apps, Izumi Sugihara, Eric Lang

Research output: Contribution to journalArticle (Academic Journal)peer-review

15 Citations (Scopus)
242 Downloads (Pure)

Abstract

Purkinje cells (PCs) generate two types of action potentials, called simple and complex spikes (SSs and CSs). We first investigated the CS-associated modulation of SS activity and its relationship to the zebrin status of the PC. The modulation pattern consisted of a pre-CS rise in SS activity, and then, following the CS, a pause, a rebound, and finally a late inhibition of SS activity for both zebrin positive (Z+) and negative (Z-) cells, though the amplitudes of the phases were larger in Z+ cells. Moreover, the amplitudes of the pre-CS rise with the late inhibitory phase of the modulation were correlated across PCs. In contrast, correlations between modulation phases across CSs of individual PCs were generally weak. Next, the relationship between CS spikelets and SS activity was investigated. The number of spikelets/CS correlated with the average SS firing rate only for Z+ cells. In contrast, correlations across CSs between spikelet numbers and the amplitudes of the SS modulation phases were generally weak. Division of spikelets into likely axonally propagated and non-propagated groups (based on their interspikelet interval) showed that the correlation of spikelet number with SS firing rate primarily reflected a relationship with non-propagated spikelets. In sum, the results show that both zebrin-related and non-zebrin-related physiological heterogeneity in SS-CS interactions among PCs, which suggests that the cerebellar cortex is more functionally diverse than is assumed by standard theories of cerebellar function.
Original languageEnglish
Number of pages17
JournalJournal of Physiology
Early online date26 Jun 2017
DOIs
Publication statusE-pub ahead of print - 26 Jun 2017

Bibliographical note

16-May-17

Keywords

  • Cerebellum
  • Inferior olive
  • Spikelet

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