Projects per year
Abstract
A facile route to hierarchically organized multicompartmentalized proteinosomes based on a recursive Pickering emulsion procedure using amphiphilic protein–polymer nanoconjugate building blocks is described. The number of incarcerated guest proteinosomes within a single host proteinosome is controlled, and enzymes and genetic polymers encapsulated within targeted subcompartments to produce chemically organized multi-tiered structures. Three types of spatiotemporal response—retarded concomitant release, synchronous release or hierarchical release of dextran and DNA—are demonstrated based on the sequential response of the host and guest membranes to attack by protease, or through variations in the positioning of disulfide-containing cross-links in either the host or guest proteinosomes integrated into the nested architectures. Overall, our studies provide a step towards the construction of hierarchically structured synthetic protocells with chemically and spatially integrated proto-organelles.
Original language | English |
---|---|
Pages (from-to) | 7095-7100 |
Number of pages | 6 |
Journal | Angewandte Chemie - International Edition |
Volume | 55 |
Issue number | 25 |
Early online date | 4 May 2016 |
DOIs | |
Publication status | Published - 13 Jun 2016 |
Keywords
- hierarchical structures
- microcapsules
- nanoconjugates
- proteinosomes
- release
Fingerprint
Dive into the research topics of 'Hierarchical Proteinosomes for Programmed Release of Multiple Components'. Together they form a unique fingerprint.Projects
- 1 Finished