HIF-1 promotes the expression of its α-subunit via an epigenetically regulated transactivation loop

D J Asby, F Cuda, F Hoakwie, E Miranda, A Tavassoli

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Hypoxia inducible factor-1 (HIF-1) directs the cellular response to low oxygen and plays a key role in tumour survival and growth. Here we use an inhibitor of the HIF-1α/HIF-1β protein-protein interaction to show the presence of an epigenetically controlled transactivation loop whereby the HIF-1 transcription factor promotes the expression of its own α-subunit in hypoxic cancer cells.

Original languageEnglish
Pages (from-to)2505-8
Number of pages4
JournalMolecular bioSystems
Volume10
Issue number10
DOIs
Publication statusPublished - Oct 2014

Keywords

  • Anoxia
  • Cell Line
  • Epigenesis, Genetic
  • Gene Expression Regulation
  • Humans
  • Hypoxia-Inducible Factor 1
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Protein Binding
  • RNA, Messenger
  • Transcriptional Activation

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