Abstract
Hypoxia inducible factor-1 (HIF-1) directs the cellular response to low oxygen and plays a key role in tumour survival and growth. Here we use an inhibitor of the HIF-1α/HIF-1β protein-protein interaction to show the presence of an epigenetically controlled transactivation loop whereby the HIF-1 transcription factor promotes the expression of its own α-subunit in hypoxic cancer cells.
Original language | English |
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Pages (from-to) | 2505-8 |
Number of pages | 4 |
Journal | Molecular bioSystems |
Volume | 10 |
Issue number | 10 |
DOIs | |
Publication status | Published - Oct 2014 |
Research Groups and Themes
- Cerebrovascular and Dementia Research Group
Keywords
- Anoxia
- Cell Line
- Epigenesis, Genetic
- Gene Expression Regulation
- Humans
- Hypoxia-Inducible Factor 1
- Hypoxia-Inducible Factor 1, alpha Subunit
- Protein Binding
- RNA, Messenger
- Transcriptional Activation