Projects per year
Abstract
Rigid preorganization is not always the best approach to molecular recognition. Unlike previous synthetic lectins, new receptors (see picture) were synthesized that possess conformational freedom which allows hydrophobically driven collapse of the cavity. Nonetheless, they bind their carbohydrate targets in water with ground-breaking affinities (up to 4500 M−1 for methyl cellobioside, R=Me) and selectivities.
Original language | English |
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Pages (from-to) | 4586-4590 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 51 |
Issue number | 19 |
Early online date | 29 Mar 2012 |
DOIs | |
Publication status | Published - 3 May 2012 |
Keywords
- biomimetic hosts
- carbohydrates
- molecular recognition
- receptors
- supramolecular chemistry
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Dive into the research topics of 'High-Affinity Disaccharide Binding by Tricyclic Synthetic Lectins'. Together they form a unique fingerprint.Projects
- 1 Finished
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SYNTHETIC LECTIS FOR OLIGOSACCHARIDE BINDING IN AQUEOUS MEDIA
Davis, A. P. (Principal Investigator)
1/06/06 → 1/08/09
Project: Research