High frequency spikes in long period blood cell oscillations

C G Colijn, A Fowler, M Mackey

Research output: Contribution to journalArticle (Academic Journal)peer-review

15 Citations (Scopus)


Several hematological diseases are characterised by oscillations of various blood cell populations. Two of these are a variant of chronic myelogenous leukemia (CML) and cyclical neutropenia (CN). These oscillations typically have long periods ranging from 20 to 60 days, despite the fact that the stem cell cycling time is thought to be of the order of 2-3 days. Clinical data from humans and laboratory data from the grey collie animal model of CN is suggestive of the idea that these long period oscillations may also contain higher frequency spiky oscillations. We show how such oscillations can be understood in the context of slow periodic stem cell oscillations, by analysing a two component differential-delay equation model of stem cell and neutrophil populations.
Translated title of the contributionHigh frequency spikes in long period blood cell oscillations
Original languageEnglish
Pages (from-to)499 - 519
Number of pages21
JournalJournal of Mathematical Biology
Volume53 (4)
Publication statusPublished - Oct 2006

Bibliographical note

Publisher: Springer


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