High precision NOEs as a probe for low level conformers-a second conformation of strychnine

Craig P. Butts; Catharine R. Jones; Jeremy N. Harvey

doi:10.1039/c0cc04114a

High precision NOEs as a probe for low level conformers-a second conformation of strychnine

Craig P. Butts^*, Catharine R. Jones, Jeremy N. Harvey

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

65 Citations (Scopus)

Abstract

A second conformer of strychnine, with a very low population (2.5%), has been identified experimentally, and confirmed by computation, demonstrating the ability of NOE measurements to discriminate minute contributions to dynamic structure ensembles in solution.

Translated title of the contribution	High precision NOEs as a probe for low level conformers - A second conformation of strychnine
Original language	English
Pages (from-to)	1193-1195
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	4
DOIs	https://doi.org/10.1039/c0cc04114a
Publication status	Published - 2011

Keywords

NMR-SPECTRA

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HIGH-FIELD NMR SPECTROSCOPY FOR BIOMOLECULAR RESEARCH
Butts, C. P.
1/03/08 → 1/03/09
Project: Research

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title = "High precision NOEs as a probe for low level conformers-a second conformation of strychnine",

abstract = "A second conformer of strychnine, with a very low population (2.5%), has been identified experimentally, and confirmed by computation, demonstrating the ability of NOE measurements to discriminate minute contributions to dynamic structure ensembles in solution.",

keywords = "NMR-SPECTRA",

author = "Butts, {Craig P.} and Jones, {Catharine R.} and Harvey, {Jeremy N.}",

year = "2011",

doi = "10.1039/c0cc04114a",

language = "English",

volume = "47",

pages = "1193--1195",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "4",

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TY - JOUR

T1 - High precision NOEs as a probe for low level conformers-a second conformation of strychnine

AU - Butts, Craig P.

AU - Jones, Catharine R.

AU - Harvey, Jeremy N.

PY - 2011

Y1 - 2011

N2 - A second conformer of strychnine, with a very low population (2.5%), has been identified experimentally, and confirmed by computation, demonstrating the ability of NOE measurements to discriminate minute contributions to dynamic structure ensembles in solution.

AB - A second conformer of strychnine, with a very low population (2.5%), has been identified experimentally, and confirmed by computation, demonstrating the ability of NOE measurements to discriminate minute contributions to dynamic structure ensembles in solution.

KW - NMR-SPECTRA

U2 - 10.1039/c0cc04114a

DO - 10.1039/c0cc04114a

M3 - Article (Academic Journal)

C2 - 21109870

SN - 1359-7345

VL - 47

SP - 1193

EP - 1195

JO - Chemical Communications

JF - Chemical Communications

IS - 4

ER -

High precision NOEs as a probe for low level conformers-a second conformation of strychnine

Abstract

Keywords

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HIGH-FIELD NMR SPECTROSCOPY FOR BIOMOLECULAR RESEARCH

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