High-speed AFM of human chromosomes in liquid

L Picco, P.G Dunton, A Ulcinas, D.J Engledew, O Hoshi, T Ushiki, M.J Miles

Research output: Contribution to journalArticle (Academic Journal)peer-review

40 Citations (Scopus)


Further developments of the previously reported high-speed contact-mode AFM are described. The technique is applied to the imaging of human chromosomes at video rate both in air and in water. These are the largest structures to have been imaged with high-speed AFM and the first imaging in liquid to be reported. A possible mechanism that allows such high-speed contact-mode imaging without significant damage to the sample is discussed in the context of the velocity dependence of the measured lateral force on the AFM tip.
Translated title of the contributionHigh-speed AFM of human chromosomes in liquid
Original languageEnglish
Article number384018
Pages (from-to)2-7
Number of pages6
Publication statusPublished - Sept 2008


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