Higher-order assembly of crystalline cylindrical micelles into membrane-extendable colloidosomes

Hongjing Dou, Mei Li, Yan Qiao, Robert Harniman, Xiaoyu Li, Charlotte E. Boott, Stephen Mann*, Ian Manners

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)
324 Downloads (Pure)

Abstract

Crystallization-driven self-Assembly of diblock copolymers into cylindrical micelles of controlled length has emerged as a promising approach to the fabrication of functional nanoscale objects with high shape anisotropy. Here we show the preparation of a series of crystallizable diblock copolymers with appropriate wettability and chemical reactivity, and demonstrate their self-Assembly into size-specific cylindrical micelle building blocks for the hierarchical construction of mechanically robust colloidosomes with a range of membrane textures, surface chemistries and optical properties. The colloidosomes can be structurally elaborated post assembly by in situ epitaxial elongation of the membrane building blocks to produce microcapsules covered in a chemically distinct, dense network of hair-like outgrowths. Our approach provides a route to hierarchically ordered colloidosomes that retain the intrinsic growth activity of their constituent building blocks to permit biofunctionalization, and have potential applications in areas such as biomimetic encapsulation, drug delivery, catalysis and biosensing.

Original languageEnglish
Article number426
Number of pages8
JournalNature Communications
Volume8
Issue number1
Early online date4 Sep 2017
DOIs
Publication statusPublished - 1 Dec 2017

Structured keywords

  • BCS and TECS CDTs

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