HIV-1 infection is associated with altered innate pulmonary immunity

Stephen B Gordon, Edward N Janoff, Dan Sloper, Qibo Zhang, Robert C Read, Eduard E Zijlstra, Adam Finn, Malcolm E Molyneux

Research output: Contribution to journalArticle (Academic Journal)peer-review

12 Citations (Scopus)

Abstract

We obtained bronchoalveolar lavage (BAL) fluid from 45 Malawian adults, to measure the concentrations of innate pulmonary immune factors that are important in lung defense against infection. Increased concentrations of the beta -chemokine RANTES were found in BAL fluid from the human immunodeficiency virus (HIV)-1-infected subjects, compared with those in BAL fluid from the HIV-1-uninfected control subjects (mean, 86 pg/mL vs. 0 pg/mL; P<.001). Lysozyme concentrations were also elevated in the HIV-1-infected subjects, compared with those in the HIV-1-uninfected control subjects (1.9 mu g/mL vs. 1.1 mu g/mL; P=.03), but were not elevated in the HIV-1-infected subjects who had recently recovered from invasive pneumococcal disease. Concentrations of lactoferrin and secretory leukocyte protease inhibitor (SLPI) were not different when the subjects were compared by HIV-1 serostatus. Concentrations of RANTES (R2=0.68 and P<.0001) and SLPI (R2=0.29 and P=.001) correlated with BAL fluid HIV-1 load but not with plasma HIV-1 load.

Original languageEnglish
Pages (from-to)1412-6
Number of pages5
JournalJournal of Infectious Diseases
Volume192
Issue number8
DOIs
Publication statusPublished - 15 Oct 2005

Keywords

  • Adult
  • Antibodies, Bacterial
  • Antibody Specificity
  • Bacterial Capsules
  • Bronchoalveolar Lavage Fluid
  • Chemokine CCL5
  • Female
  • HIV Infections
  • HIV-1
  • Humans
  • Immunity, Innate
  • Immunity, Mucosal
  • Male
  • Respiratory Tract Infections

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