HIV-1-related Hodgkin lymphoma in the era of combination antiretroviral therapy: incidence, outcome and evolution of CD4+ T cell lymphocytes

J Bohlius, K Schmidlin, F Boue, G Fatkenheuer, M May, AMC Murillo, A Mocroft, F Bonnet, G Clifford, G Touloumi, JM Miro, M Prins, G Chene, M Egger

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

The risk of Hodgkin lymphoma (HL) is increased in patients infected with HIV-1. We studied incidence and outcomes of HL, and compared CD4-positive T-cell trajectories in HL patients and controls matched for duration of combination antiretroviral therapy (cART). A total of 40 168 adult HIV-1 infected patients (median age 36 years, 70% male, median CD4 cell count 234 cells/μL) from 16 European cohorts were observed during 159 133 person-years; 78 patients developed HL. The incidence was 49.0 (95% CI 39.3 to 61.2) per 100 000 person-years, and similar on cART and not on cART (P = 0.95). The risk of HL declined as the most recent (time-updated) CD4 count increased: the adjusted hazard ratio comparing >350 with
Translated title of the contributionHIV-1-related Hodgkin lymphoma in the era of combination antiretroviral therapy: incidence, outcome and evolution of CD4+ T cell lymphocytes
Original languageEnglish
Pages (from-to)6100 - 6108
Number of pages9
JournalBlood
Volume117
Publication statusPublished - Feb 2011

Bibliographical note

Other identifier: PMID: 21368291

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