HIV integrase: A target for AIDS therapeutics

Mark Thomas; Leo Brady

doi:10.1016/S0167-7799(97)01016-0

HIV integrase: A target for AIDS therapeutics

Mark Thomas, Leo Brady

School of Biochemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

HIV integrase catalyses the incorporation of virally derived DNA into the human genome. This unique step in the virus life cycle provides a variety of points for intervention and hence is an attractive target for the development of new therapeutics for the treatment of AIDS. In this review we summarize current knowledge of the function of this enzyme and discuss some of the obstacles to the development of appropriate drugs.

Original language	English
Pages (from-to)	167-172
Number of pages	6
Journal	Trends in Biotechnology
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/S0167-7799(97)01016-0
Publication status	Published - 1 May 1997

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title = "HIV integrase: A target for AIDS therapeutics",

abstract = "HIV integrase catalyses the incorporation of virally derived DNA into the human genome. This unique step in the virus life cycle provides a variety of points for intervention and hence is an attractive target for the development of new therapeutics for the treatment of AIDS. In this review we summarize current knowledge of the function of this enzyme and discuss some of the obstacles to the development of appropriate drugs.",

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AU - Brady, Leo

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AB - HIV integrase catalyses the incorporation of virally derived DNA into the human genome. This unique step in the virus life cycle provides a variety of points for intervention and hence is an attractive target for the development of new therapeutics for the treatment of AIDS. In this review we summarize current knowledge of the function of this enzyme and discuss some of the obstacles to the development of appropriate drugs.

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JO - Trends in Biotechnology

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HIV integrase: A target for AIDS therapeutics

Abstract

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