HIV integrase: A target for AIDS therapeutics

Mark Thomas, Leo Brady

Research output: Contribution to journalArticle (Academic Journal)peer-review

41 Citations (Scopus)


HIV integrase catalyses the incorporation of virally derived DNA into the human genome. This unique step in the virus life cycle provides a variety of points for intervention and hence is an attractive target for the development of new therapeutics for the treatment of AIDS. In this review we summarize current knowledge of the function of this enzyme and discuss some of the obstacles to the development of appropriate drugs.

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalTrends in Biotechnology
Issue number5
Publication statusPublished - 1 May 1997


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