HLA-B*27 is associated with CNO in a European cohort

Daire O'Leary; Dalila Ali Al Julandani; Muhammad Zia; Jens Klotsche; Kirsten Minden; Marion Roderick; Athimalaipet V Ramanan; Orla G Killeen; Anthony G Wilson

doi:10.1186/s12969-023-00826-7

HLA-B*27 is associated with CNO in a European cohort

Daire O'Leary^*, Dalila Ali Al Julandani, Muhammad Zia, Jens Klotsche, Kirsten Minden, Marion Roderick, Athimalaipet V Ramanan, Orla G Killeen, Anthony G Wilson

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

2 Citations (Scopus)

Abstract

OBJECTIVES: To determine the influence of HLA-B27 positivity on risk of developing chronic nonbacterial osteomyelitis (CNO).

METHODS: HLA-B*27 genotype was assessed in 3 European CNO populations and compared with local control populations (572 cases, 33,256 controls). Regional or whole-body MRI was performed at diagnosis and follow-up in all cases which reduces the risk of disease misclassification. Genotyping was performed using either next generation DNA sequencing or PCR based molecular typing. Statistical analysis used Fisher's exact test with Bonferroni correction and a fixed effects model for meta-analysis of odds ratios.

RESULTS: HLA-B*27 frequency was higher in all 3 populations compared with local controls (combined odds ratio (OR) = 2.2, p-value = 3 × 10-11). This association was much stronger in male compared with female cases (OR = 1.99, corrected p-value = 0.015). However, the HLA-B*27 status was not statistically significantly associated with co-occurrence of psoriasis, arthritis or inflammatory bowel disease.

CONCLUSION: Carriage of HLA-B*27 is associated with greater risk of developing CNO, particularly in male cases.

Original language	English
Pages (from-to)	52
Number of pages	6
Journal	Pediatric rheumatology online journal
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s12969-023-00826-7
Publication status	Published - 5 Jun 2023

Bibliographical note

Keywords

Humans
Male
Female
Osteomyelitis/diagnosis
Psoriasis
HLA-B Antigens/genetics
HLA-B27 Antigen/genetics

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@article{2098eba4883648ba82c44277d2ef7d4b,

title = "HLA-B*27 is associated with CNO in a European cohort",

abstract = "OBJECTIVES: To determine the influence of HLA-B27 positivity on risk of developing chronic nonbacterial osteomyelitis (CNO).METHODS: HLA-B*27 genotype was assessed in 3 European CNO populations and compared with local control populations (572 cases, 33,256 controls). Regional or whole-body MRI was performed at diagnosis and follow-up in all cases which reduces the risk of disease misclassification. Genotyping was performed using either next generation DNA sequencing or PCR based molecular typing. Statistical analysis used Fisher's exact test with Bonferroni correction and a fixed effects model for meta-analysis of odds ratios.RESULTS: HLA-B*27 frequency was higher in all 3 populations compared with local controls (combined odds ratio (OR) = 2.2, p-value = 3 × 10-11). This association was much stronger in male compared with female cases (OR = 1.99, corrected p-value = 0.015). However, the HLA-B*27 status was not statistically significantly associated with co-occurrence of psoriasis, arthritis or inflammatory bowel disease.CONCLUSION: Carriage of HLA-B*27 is associated with greater risk of developing CNO, particularly in male cases.",

keywords = "Humans, Male, Female, Osteomyelitis/diagnosis, Psoriasis, HLA-B Antigens/genetics, HLA-B27 Antigen/genetics",

author = "Daire O'Leary and \{Al Julandani\}, \{Dalila Ali\} and Muhammad Zia and Jens Klotsche and Kirsten Minden and Marion Roderick and Ramanan, \{Athimalaipet V\} and Killeen, \{Orla G\} and Wilson, \{Anthony G\}",

note = "{\textcopyright} 2023. The Author(s).",

year = "2023",

month = jun,

day = "5",

doi = "10.1186/s12969-023-00826-7",

language = "English",

volume = "21",

pages = "52",

journal = "Pediatric rheumatology online journal",

issn = "1546-0096",

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number = "1",

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TY - JOUR

T1 - HLA-B*27 is associated with CNO in a European cohort

AU - O'Leary, Daire

AU - Al Julandani, Dalila Ali

AU - Zia, Muhammad

AU - Klotsche, Jens

AU - Minden, Kirsten

AU - Roderick, Marion

AU - Ramanan, Athimalaipet V

AU - Killeen, Orla G

AU - Wilson, Anthony G

PY - 2023/6/5

Y1 - 2023/6/5

N2 - OBJECTIVES: To determine the influence of HLA-B27 positivity on risk of developing chronic nonbacterial osteomyelitis (CNO).METHODS: HLA-B*27 genotype was assessed in 3 European CNO populations and compared with local control populations (572 cases, 33,256 controls). Regional or whole-body MRI was performed at diagnosis and follow-up in all cases which reduces the risk of disease misclassification. Genotyping was performed using either next generation DNA sequencing or PCR based molecular typing. Statistical analysis used Fisher's exact test with Bonferroni correction and a fixed effects model for meta-analysis of odds ratios.RESULTS: HLA-B*27 frequency was higher in all 3 populations compared with local controls (combined odds ratio (OR) = 2.2, p-value = 3 × 10-11). This association was much stronger in male compared with female cases (OR = 1.99, corrected p-value = 0.015). However, the HLA-B*27 status was not statistically significantly associated with co-occurrence of psoriasis, arthritis or inflammatory bowel disease.CONCLUSION: Carriage of HLA-B*27 is associated with greater risk of developing CNO, particularly in male cases.

AB - OBJECTIVES: To determine the influence of HLA-B27 positivity on risk of developing chronic nonbacterial osteomyelitis (CNO).METHODS: HLA-B*27 genotype was assessed in 3 European CNO populations and compared with local control populations (572 cases, 33,256 controls). Regional or whole-body MRI was performed at diagnosis and follow-up in all cases which reduces the risk of disease misclassification. Genotyping was performed using either next generation DNA sequencing or PCR based molecular typing. Statistical analysis used Fisher's exact test with Bonferroni correction and a fixed effects model for meta-analysis of odds ratios.RESULTS: HLA-B*27 frequency was higher in all 3 populations compared with local controls (combined odds ratio (OR) = 2.2, p-value = 3 × 10-11). This association was much stronger in male compared with female cases (OR = 1.99, corrected p-value = 0.015). However, the HLA-B*27 status was not statistically significantly associated with co-occurrence of psoriasis, arthritis or inflammatory bowel disease.CONCLUSION: Carriage of HLA-B*27 is associated with greater risk of developing CNO, particularly in male cases.

KW - Humans

KW - Male

KW - Female

KW - Osteomyelitis/diagnosis

KW - Psoriasis

KW - HLA-B Antigens/genetics

KW - HLA-B27 Antigen/genetics

U2 - 10.1186/s12969-023-00826-7

DO - 10.1186/s12969-023-00826-7

M3 - Article (Academic Journal)

C2 - 37277844

SN - 1546-0096

VL - 21

SP - 52

JO - Pediatric rheumatology online journal

JF - Pediatric rheumatology online journal

IS - 1

ER -

HLA-B*27 is associated with CNO in a European cohort

Abstract

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