Honey bee Royalactin unlocks conserved pluripotency pathway in mammals

Derrick C Wan; Stefanie L Morgan; Andrew L Spencley; Natasha Mariano; Erin Y Chang; Gautam Shankar; Yunhai Luo; Ted H Li; Dana Huh; Star K Huynh; Jasmine M Garcia; Cole M Dovey; Jennifer Lumb; Ling Liu; Katharine V Brown; Abel Bermudez; Richard Luong; Hong Zeng; Victoria L Mascetti; Sharon J Pitteri; Jordon Wang; Hua Tu; Marco Quarta; Vittorio Sebastiano; Roel Nusse; Thomas A Rando; Jan E Carette; J Fernando Bazan; Kevin C Wang

doi:10.1038/s41467-018-06256-4

Honey bee Royalactin unlocks conserved pluripotency pathway in mammals

Derrick C Wan, Stefanie L Morgan, Andrew L Spencley, Natasha Mariano, Erin Y Chang, Gautam Shankar, Yunhai Luo, Ted H Li, Dana Huh, Star K Huynh, Jasmine M Garcia, Cole M Dovey, Jennifer Lumb, Ling Liu, Katharine V Brown, Abel Bermudez, Richard Luong, Hong Zeng, Victoria L Mascetti, Sharon J PitteriJordon Wang, Hua Tu, Marco Quarta, Vittorio Sebastiano, Roel Nusse, Thomas A Rando, Jan E Carette, J Fernando Bazan, Kevin C Wang

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

16 Citations (Scopus)

Abstract

Royal jelly is the queen-maker for the honey bee Apis mellifera, and has cross-species effects on longevity, fertility, and regeneration in mammals. Despite this knowledge, how royal jelly or its components exert their myriad effects has remained poorly understood. Using mouse embryonic stem cells as a platform, here we report that through its major protein component Royalactin, royal jelly can maintain pluripotency by activating a ground-state pluripotency-like gene network. We further identify Regina, a mammalian structural analog of Royalactin that also induces a naive-like state in mouse embryonic stem cells. This reveals an important innate program for stem cell self-renewal with broad implications in understanding the molecular regulation of stem cell fate across species.

Original language	English
Article number	5078
Journal	Nature Communications
Volume	9
DOIs	https://doi.org/10.1038/s41467-018-06256-4
Publication status	Published - 4 Dec 2018

Keywords

Animals
Bees/metabolism
Chromatin
Fatty Acids/chemistry
Female
Fertility
Gene Expression Regulation, Developmental/drug effects
Glycoproteins/chemistry
Insect Proteins/chemistry
Lentivirus/genetics
Longevity
Mammals/physiology
Mice
Models, Molecular
Mouse Embryonic Stem Cells/drug effects
Pluripotent Stem Cells/drug effects
Recombinant Proteins
Teratoma/pathology
Ubiquitin-Protein Ligases/genetics

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10.1038/s41467-018-06256-4

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Dr Victoria Mascetti
- victoria.mascettibristol.acuk
- ql19682bristol.acuk
- Bristol Medical School (THS) - Vice Chancellor's Fellow
Person: Academic

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Wan, D. C., Morgan, S. L., Spencley, A. L., Mariano, N., Chang, E. Y., Shankar, G., Luo, Y., Li, T. H., Huh, D., Huynh, S. K., Garcia, J. M., Dovey, C. M., Lumb, J., Liu, L., Brown, K. V., Bermudez, A., Luong, R., Zeng, H., Mascetti, V. L., ... Wang, K. C. (2018). Honey bee Royalactin unlocks conserved pluripotency pathway in mammals. Nature Communications, 9, [5078]. https://doi.org/10.1038/s41467-018-06256-4

@article{4ad857a1841f42249bf4cf759e8562a6,

title = "Honey bee Royalactin unlocks conserved pluripotency pathway in mammals",

abstract = "Royal jelly is the queen-maker for the honey bee Apis mellifera, and has cross-species effects on longevity, fertility, and regeneration in mammals. Despite this knowledge, how royal jelly or its components exert their myriad effects has remained poorly understood. Using mouse embryonic stem cells as a platform, here we report that through its major protein component Royalactin, royal jelly can maintain pluripotency by activating a ground-state pluripotency-like gene network. We further identify Regina, a mammalian structural analog of Royalactin that also induces a naive-like state in mouse embryonic stem cells. This reveals an important innate program for stem cell self-renewal with broad implications in understanding the molecular regulation of stem cell fate across species.",

keywords = "Animals, Bees/metabolism, Chromatin, Fatty Acids/chemistry, Female, Fertility, Gene Expression Regulation, Developmental/drug effects, Glycoproteins/chemistry, Insect Proteins/chemistry, Lentivirus/genetics, Longevity, Mammals/physiology, Mice, Models, Molecular, Mouse Embryonic Stem Cells/drug effects, Pluripotent Stem Cells/drug effects, Recombinant Proteins, Teratoma/pathology, Ubiquitin-Protein Ligases/genetics",

author = "Wan, {Derrick C} and Morgan, {Stefanie L} and Spencley, {Andrew L} and Natasha Mariano and Chang, {Erin Y} and Gautam Shankar and Yunhai Luo and Li, {Ted H} and Dana Huh and Huynh, {Star K} and Garcia, {Jasmine M} and Dovey, {Cole M} and Jennifer Lumb and Ling Liu and Brown, {Katharine V} and Abel Bermudez and Richard Luong and Hong Zeng and Mascetti, {Victoria L} and Pitteri, {Sharon J} and Jordon Wang and Hua Tu and Marco Quarta and Vittorio Sebastiano and Roel Nusse and Rando, {Thomas A} and Carette, {Jan E} and Bazan, {J Fernando} and Wang, {Kevin C}",

year = "2018",

month = dec,

day = "4",

doi = "10.1038/s41467-018-06256-4",

language = "English",

volume = "9",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Springer Nature",

}

Wan, DC, Morgan, SL, Spencley, AL, Mariano, N, Chang, EY, Shankar, G, Luo, Y, Li, TH, Huh, D, Huynh, SK, Garcia, JM, Dovey, CM, Lumb, J, Liu, L, Brown, KV, Bermudez, A, Luong, R, Zeng, H, Mascetti, VL, Pitteri, SJ, Wang, J, Tu, H, Quarta, M, Sebastiano, V, Nusse, R, Rando, TA, Carette, JE, Bazan, JF & Wang, KC 2018, 'Honey bee Royalactin unlocks conserved pluripotency pathway in mammals', Nature Communications, vol. 9, 5078. https://doi.org/10.1038/s41467-018-06256-4

TY - JOUR

T1 - Honey bee Royalactin unlocks conserved pluripotency pathway in mammals

AU - Wan, Derrick C

AU - Morgan, Stefanie L

AU - Spencley, Andrew L

AU - Mariano, Natasha

AU - Chang, Erin Y

AU - Shankar, Gautam

AU - Luo, Yunhai

AU - Li, Ted H

AU - Huh, Dana

AU - Huynh, Star K

AU - Garcia, Jasmine M

AU - Dovey, Cole M

AU - Lumb, Jennifer

AU - Liu, Ling

AU - Brown, Katharine V

AU - Bermudez, Abel

AU - Luong, Richard

AU - Zeng, Hong

AU - Mascetti, Victoria L

AU - Pitteri, Sharon J

AU - Wang, Jordon

AU - Tu, Hua

AU - Quarta, Marco

AU - Sebastiano, Vittorio

AU - Nusse, Roel

AU - Rando, Thomas A

AU - Carette, Jan E

AU - Bazan, J Fernando

AU - Wang, Kevin C

PY - 2018/12/4

Y1 - 2018/12/4

N2 - Royal jelly is the queen-maker for the honey bee Apis mellifera, and has cross-species effects on longevity, fertility, and regeneration in mammals. Despite this knowledge, how royal jelly or its components exert their myriad effects has remained poorly understood. Using mouse embryonic stem cells as a platform, here we report that through its major protein component Royalactin, royal jelly can maintain pluripotency by activating a ground-state pluripotency-like gene network. We further identify Regina, a mammalian structural analog of Royalactin that also induces a naive-like state in mouse embryonic stem cells. This reveals an important innate program for stem cell self-renewal with broad implications in understanding the molecular regulation of stem cell fate across species.

AB - Royal jelly is the queen-maker for the honey bee Apis mellifera, and has cross-species effects on longevity, fertility, and regeneration in mammals. Despite this knowledge, how royal jelly or its components exert their myriad effects has remained poorly understood. Using mouse embryonic stem cells as a platform, here we report that through its major protein component Royalactin, royal jelly can maintain pluripotency by activating a ground-state pluripotency-like gene network. We further identify Regina, a mammalian structural analog of Royalactin that also induces a naive-like state in mouse embryonic stem cells. This reveals an important innate program for stem cell self-renewal with broad implications in understanding the molecular regulation of stem cell fate across species.

KW - Animals

KW - Bees/metabolism

KW - Chromatin

KW - Fatty Acids/chemistry

KW - Female

KW - Fertility

KW - Gene Expression Regulation, Developmental/drug effects

KW - Glycoproteins/chemistry

KW - Insect Proteins/chemistry

KW - Lentivirus/genetics

KW - Longevity

KW - Mammals/physiology

KW - Mice

KW - Models, Molecular

KW - Mouse Embryonic Stem Cells/drug effects

KW - Pluripotent Stem Cells/drug effects

KW - Recombinant Proteins

KW - Teratoma/pathology

KW - Ubiquitin-Protein Ligases/genetics

U2 - 10.1038/s41467-018-06256-4

DO - 10.1038/s41467-018-06256-4

M3 - Article (Academic Journal)

C2 - 30510260

SN - 2041-1723

VL - 9

JO - Nature Communications

JF - Nature Communications

M1 - 5078

ER -

Honey bee Royalactin unlocks conserved pluripotency pathway in mammals

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Keywords

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