Hormonal mechanisms underlying the relationship between obesity and breast cancer

CM Perks; JMP Holly

doi:10.1016/j.ecl.2011.05.010

Hormonal mechanisms underlying the relationship between obesity and breast cancer

CM Perks, JMP Holly

Research output: Contribution to journal › Article (Academic Journal) › peer-review

35 Citations (Scopus)

Abstract

Given the worldwide epidemic of obesity, it is inevitably an increasingly common comorbidity for women who develop breast cancer; therefore, it is critical to understand its impact on this disease. This review focuses on the influence of obesity on breast cancer development and progression and describes the hormonal factors that may underlie the observations, with particular emphasis on the roles of estrogen, insulin/insulin-like growth factor axis, and adipokines.

Translated title of the contribution	Hormonal mechanisms underlying the relationship between obesity and breast cancer
Original language	English
Pages (from-to)	485 - 507
Number of pages	13
Journal	Endocrinology and Metabolism Clinics of North America
Volume	40(3)
DOIs	https://doi.org/10.1016/j.ecl.2011.05.010
Publication status	Published - Sep 2011

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title = "Hormonal mechanisms underlying the relationship between obesity and breast cancer",

abstract = "Given the worldwide epidemic of obesity, it is inevitably an increasingly common comorbidity for women who develop breast cancer; therefore, it is critical to understand its impact on this disease. This review focuses on the influence of obesity on breast cancer development and progression and describes the hormonal factors that may underlie the observations, with particular emphasis on the roles of estrogen, insulin/insulin-like growth factor axis, and adipokines.",

author = "CM Perks and JMP Holly",

year = "2011",

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T1 - Hormonal mechanisms underlying the relationship between obesity and breast cancer

AU - Perks, CM

AU - Holly, JMP

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AB - Given the worldwide epidemic of obesity, it is inevitably an increasingly common comorbidity for women who develop breast cancer; therefore, it is critical to understand its impact on this disease. This review focuses on the influence of obesity on breast cancer development and progression and describes the hormonal factors that may underlie the observations, with particular emphasis on the roles of estrogen, insulin/insulin-like growth factor axis, and adipokines.

U2 - 10.1016/j.ecl.2011.05.010

DO - 10.1016/j.ecl.2011.05.010

M3 - Article (Academic Journal)

C2 - 21889716

VL - 40(3)

SP - 485

EP - 507

JO - Endocrinology and Metabolism Clinics of North America

JF - Endocrinology and Metabolism Clinics of North America

SN - 0889-8529

ER -