Hormonal mechanisms underlying the relationship between obesity and breast cancer

CM Perks, JMP Holly

Research output: Contribution to journalArticle (Academic Journal)peer-review

35 Citations (Scopus)

Abstract

Given the worldwide epidemic of obesity, it is inevitably an increasingly common comorbidity for women who develop breast cancer; therefore, it is critical to understand its impact on this disease. This review focuses on the influence of obesity on breast cancer development and progression and describes the hormonal factors that may underlie the observations, with particular emphasis on the roles of estrogen, insulin/insulin-like growth factor axis, and adipokines.
Translated title of the contributionHormonal mechanisms underlying the relationship between obesity and breast cancer
Original languageEnglish
Pages (from-to)485 - 507
Number of pages13
JournalEndocrinology and Metabolism Clinics of North America
Volume40(3)
DOIs
Publication statusPublished - Sep 2011

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