Given the worldwide epidemic of obesity, it is inevitably an increasingly common comorbidity for women who develop breast cancer; therefore, it is critical to understand its impact on this disease. This review focuses on the influence of obesity on breast cancer development and progression and describes the hormonal factors that may underlie the observations, with particular emphasis on the roles of estrogen, insulin/insulin-like growth factor axis, and adipokines.
|Translated title of the contribution||Hormonal mechanisms underlying the relationship between obesity and breast cancer|
|Pages (from-to)||485 - 507|
|Number of pages||13|
|Journal||Endocrinology and Metabolism Clinics of North America|
|Publication status||Published - Sep 2011|