Abstract
OBJECTIVES: Osteolysis and subsequent prosthesis loosening is the most common cause for revision following total knee arthroplasty (TKA) or total hip arthroplasty (THA). Hormone replacement therapy (HRT) could reduce osteolysis through its antiresorptive effects. We studied whether HRT use is associated with reduced revision rates in a community-based cohort of women undergoing TKA or THA for osteoarthritis. METHODS: Female participants in the General Practice Research Database undergoing a primary TKA or THA from 1986 to 2006 were included. We excluded patients aged
Original language | English |
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Pages (from-to) | 557-563 |
Number of pages | 7 |
Journal | Annals of the Rheumatic Diseases |
Volume | 74 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2015 |
Keywords
- Epidemiology
- Knee Osteoarthritis
- Orthopedic Surgery
- Osteoarthritis
- Aged
- Arthroplasty, Replacement, Hip
- Arthroplasty, Replacement, Knee
- Cohort Studies
- Estrogen Replacement Therapy
- Female
- Humans
- Medication Adherence
- Middle Aged
- Osteoarthritis, Hip
- Osteoarthritis, Knee
- Proportional Hazards Models
- Prosthesis Failure
- Reoperation
- Retrospective Studies