Hormone replacement therapy and mid-term implant survival following knee or hip arthroplasty for osteoarthritis: a population-based cohort study.

D. Prieto-Alhambra, M.K. Javaid, A. Judge, Joe Maskell, C. Cooper, N.K. Arden, COASt Study Group

Research output: Contribution to journalArticle (Academic Journal)peer-review

20 Citations (Scopus)

Abstract

OBJECTIVES: Osteolysis and subsequent prosthesis loosening is the most common cause for revision following total knee arthroplasty (TKA) or total hip arthroplasty (THA). Hormone replacement therapy (HRT) could reduce osteolysis through its antiresorptive effects. We studied whether HRT use is associated with reduced revision rates in a community-based cohort of women undergoing TKA or THA for osteoarthritis. METHODS: Female participants in the General Practice Research Database undergoing a primary TKA or THA from 1986 to 2006 were included. We excluded patients aged
Original languageEnglish
Pages (from-to)557-563
Number of pages7
JournalAnnals of the Rheumatic Diseases
Volume74
Issue number3
DOIs
Publication statusPublished - Mar 2015

Keywords

  • Epidemiology
  • Knee Osteoarthritis
  • Orthopedic Surgery
  • Osteoarthritis
  • Aged
  • Arthroplasty, Replacement, Hip
  • Arthroplasty, Replacement, Knee
  • Cohort Studies
  • Estrogen Replacement Therapy
  • Female
  • Humans
  • Medication Adherence
  • Middle Aged
  • Osteoarthritis, Hip
  • Osteoarthritis, Knee
  • Proportional Hazards Models
  • Prosthesis Failure
  • Reoperation
  • Retrospective Studies

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