How an appreciation of dynamics has altered our understanding of the HPA axis

Stafford Lightman*, Thomas Upton

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Rhythmicity is a intrinsic feature of biological systems, including the hypothalamic-pituitary-adrenal axis, a mammalian neurohormonal system crucial both in daily life and as a network that responds to stressful stimuli. Circadian and ultradian rhythmicity underlie HPA activity in rodents and in humans, regulating gene expression, metabolism and behavior, and adverse consequences occur when rhythms are disturbed. In the assessment of human disease, the complexity of HPA rhythmicity is rarely acknowledged or understood, and is currently a limitation to better diagnosis and treatment. However, the recent emergence of ambulatory, high frequency and blood-free hormone sampling techniques has the promise to substantially change our understanding of the function of HPA axis in healthy normal life, and provide new opportunities for the diagnosis and treatment of disease.

Original languageEnglish
Article number2297371
JournalStress
Volume27
Issue number1
DOIs
Publication statusPublished - 23 Jan 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • Humans
  • Animals
  • Hypothalamo-Hypophyseal System
  • Pituitary-Adrenal System
  • Stress, Psychological
  • Health Status
  • Mammals

Fingerprint

Dive into the research topics of 'How an appreciation of dynamics has altered our understanding of the HPA axis'. Together they form a unique fingerprint.

Cite this