How the complex pharmacology of the fentanyls contributes to their lethality

Graeme Henderson; Eamonn Kelly; Hannah Gill

doi:10.1111/add.14614

How the complex pharmacology of the fentanyls contributes to their lethality

Graeme Henderson^*, Eamonn Kelly, Hannah Gill

^*Corresponding author for this work

Research output: Contribution to journal › Editorial (Academic Journal) › peer-review

22 Citations (Scopus)

212 Downloads (Pure)

Abstract

Fentanyls as a class of drug have pharmacological properties that make them more likely to lead to overdose than other opioids. In addition to their high potency and rapid onset of action these drugs induce respiratory muscle stiffness making it difficult to breath, are less sensitive than heroin to naloxone reversal and may show reduced cross tolerance to other opioids.

Original language	English
Number of pages	2
Journal	Addiction
DOIs	https://doi.org/10.1111/add.14614
Publication status	Published - 17 Apr 2019

Keywords

fentanyl
heroin
muscle stiffness
naloxone
overdose
respiratory depression

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10.1111/add.14614

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This is the final published version of the article (version of record). It first appeared online via Wiley at https://onlinelibrary.wiley.com/doi/full/10.1111/add.14614 . Please refer to any applicable terms of use of the publisher.
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title = "How the complex pharmacology of the fentanyls contributes to their lethality",

abstract = "Fentanyls as a class of drug have pharmacological properties that make them more likely to lead to overdose than other opioids. In addition to their high potency and rapid onset of action these drugs induce respiratory muscle stiffness making it difficult to breath, are less sensitive than heroin to naloxone reversal and may show reduced cross tolerance to other opioids. ",

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AU - Kelly, Eamonn

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AB - Fentanyls as a class of drug have pharmacological properties that make them more likely to lead to overdose than other opioids. In addition to their high potency and rapid onset of action these drugs induce respiratory muscle stiffness making it difficult to breath, are less sensitive than heroin to naloxone reversal and may show reduced cross tolerance to other opioids.

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KW - heroin

KW - muscle stiffness

KW - naloxone

KW - overdose

KW - respiratory depression

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DO - 10.1111/add.14614

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How the complex pharmacology of the fentanyls contributes to their lethality

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Fentanyl Overdose Deaths: Underlying Mechanisms

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How the complex pharmacology of the fentanyls contributes to their lethality

Abstract

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Fentanyl Overdose Deaths: Underlying Mechanisms

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