How the complex pharmacology of the fentanyls contributes to their lethality

Graeme Henderson; Eamonn Kelly; Hannah Gill

doi:10.1111/add.14614

How the complex pharmacology of the fentanyls contributes to their lethality

Graeme Henderson^*, Eamonn Kelly, Hannah Gill

^*Corresponding author for this work

Research output: Contribution to journal › Editorial (Academic Journal) › peer-review

34 Citations (Scopus)

261 Downloads (Pure)

Abstract

Fentanyls as a class of drug have pharmacological properties that make them more likely to lead to overdose than other opioids. In addition to their high potency and rapid onset of action these drugs induce respiratory muscle stiffness making it difficult to breath, are less sensitive than heroin to naloxone reversal and may show reduced cross tolerance to other opioids.

Original language	English
Number of pages	2
Journal	Addiction
DOIs	https://doi.org/10.1111/add.14614
Publication status	Published - 17 Apr 2019

Keywords

fentanyl
heroin
muscle stiffness
naloxone
overdose
respiratory depression

Access to Document

10.1111/add.14614

Full-text PDF (final published version)
This is the final published version of the article (version of record). It first appeared online via Wiley at https://onlinelibrary.wiley.com/doi/full/10.1111/add.14614 . Please refer to any applicable terms of use of the publisher.
Final published version, 151 KBLicence: CC BY

Handle.net

Persistent link

Cite this

@article{1973cd553c9047419a5d989d5158c38d,

title = "How the complex pharmacology of the fentanyls contributes to their lethality",

abstract = "Fentanyls as a class of drug have pharmacological properties that make them more likely to lead to overdose than other opioids. In addition to their high potency and rapid onset of action these drugs induce respiratory muscle stiffness making it difficult to breath, are less sensitive than heroin to naloxone reversal and may show reduced cross tolerance to other opioids. ",

keywords = "fentanyl, heroin, muscle stiffness, naloxone, overdose, respiratory depression",

author = "Graeme Henderson and Eamonn Kelly and Hannah Gill",

year = "2019",

month = apr,

day = "17",

doi = "10.1111/add.14614",

language = "English",

journal = "Addiction",

issn = "0965-2140",

publisher = "Wiley",

}

TY - JOUR

T1 - How the complex pharmacology of the fentanyls contributes to their lethality

AU - Henderson, Graeme

AU - Kelly, Eamonn

AU - Gill, Hannah

PY - 2019/4/17

Y1 - 2019/4/17

N2 - Fentanyls as a class of drug have pharmacological properties that make them more likely to lead to overdose than other opioids. In addition to their high potency and rapid onset of action these drugs induce respiratory muscle stiffness making it difficult to breath, are less sensitive than heroin to naloxone reversal and may show reduced cross tolerance to other opioids.

AB - Fentanyls as a class of drug have pharmacological properties that make them more likely to lead to overdose than other opioids. In addition to their high potency and rapid onset of action these drugs induce respiratory muscle stiffness making it difficult to breath, are less sensitive than heroin to naloxone reversal and may show reduced cross tolerance to other opioids.

KW - fentanyl

KW - heroin

KW - muscle stiffness

KW - naloxone

KW - overdose

KW - respiratory depression

UR - http://www.scopus.com/inward/record.url?scp=85064567219&partnerID=8YFLogxK

U2 - 10.1111/add.14614

DO - 10.1111/add.14614

M3 - Editorial (Academic Journal)

C2 - 30883941

AN - SCOPUS:85064567219

SN - 0965-2140

JO - Addiction

JF - Addiction

ER -

How the complex pharmacology of the fentanyls contributes to their lethality

Abstract

Keywords

Access to Document

Handle.net

Other files and links

Embargoed Document

Fingerprint

Fentanyl Overdose Deaths: Underlying Mechanisms

Cite this

How the complex pharmacology of the fentanyls contributes to their lethality

Abstract

Keywords

Access to Document

Handle.net

Other files and links

Embargoed Document

Fingerprint

Projects

Fentanyl Overdose Deaths: Underlying Mechanisms

Cite this