How to prepare and manage a systematic review and meta-analysis of clinical studies

James Berstock*, Michael Whitehouse

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

3 Citations (Scopus)
238 Downloads (Pure)

Abstract

Use the PICO framework to formulate a specific clinical question.Formulate a search strategy.Prospectively register the review protocol.Execute the literature search.Apply eligibility criteria to exclude irrelevant studies.Extract data and appraise each study for risk of bias and external validity.Provide a narrative review.If appropriate data are available, perform a meta-analysis.Report the review findings in the context of the risk of bias assessment, any sensitivity analyses and the analysis of risk of publication bias.Useful resources include the Cochrane Handbook, PROSPERO, GRADE and PRISMA. Cite this article: EFORT Open Rev 2019;4:213-220. DOI: 10.1302/2058-5241.4.180049.

Original languageEnglish
Pages (from-to)213-220
Number of pages8
JournalEFORT Open Reviews
Volume4
Issue number5
Early online date28 May 2019
DOIs
Publication statusPublished - May 2019

Structured keywords

  • Centre for Surgical Research

Keywords

  • Meta-analysis
  • Orthopaedics
  • Review
  • Systematic review

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