How to turn a genetic circuit into a synthetic tunable oscillator, or a bistable switch

Lucia Marucci, DAW Barton, I Cantone, MA Ricci, MP Cosma, S Santini, D di Bernardo, M Di Bernardo

Research output: Contribution to journalArticle (Academic Journal)peer-review

33 Citations (Scopus)

Abstract

Systems and Synthetic Biology use computational models of biological pathways in order to study in silico the behaviour of biological pathways. Mathematical models allow to verify biological hypotheses and to predict new possible dynamical behaviours. Here we use the tools of non-linear analysis to understand how to change the dynamics of the genes composing a novel synthetic network recently constructed in the yeast Saccharomyces Cerevisiae for In-vivo Reverse-engineering and Modelling Assessment (IRMA). Guided by previous theoretical results that link the dynamics of a biological network to its topological properties, through the use of simulation and continuation techniques, we found that the network can be easily turned into a robust and tunable synthetic oscillator, or a bistable switch. Our results provide guidelines to properly re-engineering in vivo natural and synthetic networks in order to tune their dynamics.
Translated title of the contributionHow to turn a genetic circuit into a synthetic tunable oscillator, or a bistable switch
Original languageEnglish
Pages (from-to)e8083
JournalPLoS ONE
Volume4
Issue number12
DOIs
Publication statusPublished - 7 Dec 2009

Structured keywords

  • Bristol BioDesign Institute

Keywords

  • synthetic biology

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