Human African trypanosomiasis: diagnosis, relapse and survival after severe melarsoprol-induced encephalopathy

AM Checkley, J Pepin, WC Gibson, MN Taylor, HR Jäger, DC Mabey

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Abstract

We describe a case of human African trypanosomiasis with a number of unusual features. The clinical presentation was subacute, but the infection was shown to be due to Trypanosoma brucei rhodesiense. The infection relapsed twice following treatment and the patient developed a melarsoprol-associated encephalopathy. Magnetic resonance imaging (MRI) findings were suggestive of microhaemorrhages, well described in autopsy studies of encephalopathy but never before shown on MRI. The patient survived severe encephalopathy with a locked-in syndrome. Our decision to provide ongoing life support may be useful to physicians treating similar cases in a setting where intensive care facilities are available.
Translated title of the contributionHuman African trypanosomiasis: diagnosis, relapse and survival after severe melarsoprol-induced encephalopathy
Original languageEnglish
Pages (from-to)523 - 526
Number of pages4
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume101 (5)
DOIs
Publication statusPublished - May 2007

Bibliographical note

Publisher: Elsevier

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