Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop

Blanca Rodriguez, Annamaria Carusi, Najah Abi-Gerges, Rina Ariga, Oliver Britton, Gil Bub, Alfonso Bueno-Orovio, Rebecca A B Burton, Valentina Carapella, Louie Cardone-Noott, Matthew J Daniels, Mark R Davies, Sara Dutta, Andre Ghetti, Vicente Grau, Stephen Harmer, Ivan Kopljar, Pier Lambiase, Hua Rong Lu, Aurore LyonAna Minchole, Anna Muszkiewicz, Julien Oster, Michelangelo Paci, Elisa Passini, Stefano Severi, Peter Taggart, Andy Tinker, Jean-Pierre Valentin, Andras Varro, Mikael Wallman, Xin Zhou

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

Both biomedical research and clinical practice rely on complex datasets for the physiological and genetic characterization of human hearts in health and disease. Given the complexity and variety of approaches and recordings, there is now growing recognition of the need to embed computational methods in cardiovascular medicine and science for analysis, integration and prediction. This paper describes a Workshop on Computational Cardiovascular Science that created an international, interdisciplinary and inter-sectorial forum to define the next steps for a human-based approach to disease supported by computational methodologies. The main ideas highlighted were (i) a shift towards human-based methodologies, spurred by advances in new in silico, in vivo, in vitro, and ex vivo techniques and the increasing acknowledgement of the limitations of animal models. (ii) Computational approaches complement, expand, bridge, and integrate in vitro, in vivo, and ex vivo experimental and clinical data and methods, and as such they are an integral part of human-based methodologies in pharmacology and medicine. (iii) The effective implementation of multi- and interdisciplinary approaches, teams, and training combining and integrating computational methods with experimental and clinical approaches across academia, industry, and healthcare settings is a priority. (iv) The human-based cross-disciplinary approach requires experts in specific methodologies and domains, who also have the capacity to communicate and collaborate across disciplines and cross-sector environments. (v) This new translational domain for human-based cardiology and pharmacology requires new partnerships supported financially and institutionally across sectors. Institutional, organizational, and social barriers must be identified, understood and overcome in each specific setting.

Original languageEnglish
Pages (from-to)1287-1298
Number of pages12
JournalEP-Europace
Volume18
Issue number9
Early online date29 Nov 2015
DOIs
Publication statusPublished - 1 Sep 2016

Bibliographical note

© The Author 2015. Published by Oxford University Press on behalf of the European Society of Cardiology.

Keywords

  • Animals
  • Biomarkers/metabolism
  • Cardiac Imaging Techniques
  • Cardiology/methods
  • Cardiotoxicity
  • Cardiovascular Agents/adverse effects
  • Cooperative Behavior
  • Diffusion of Innovation
  • Electrophysiologic Techniques, Cardiac
  • Heart Diseases/diagnostic imaging
  • Humans
  • Interdisciplinary Communication
  • Models, Cardiovascular
  • Patient-Specific Modeling
  • Pharmacology/methods
  • Predictive Value of Tests
  • Prognosis
  • Public-Private Sector Partnerships
  • Translational Medical Research/methods

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