Human mesenchymal stem cells infiltrate the spinal cord, reduce demyelination, and localize to white matter lesions in experimental autoimmune encephalomyelitis

D Gordon, G Pavlovska, JB Uney, DC Wraith, N Scolding

Research output: Contribution to journalArticle (Academic Journal)peer-review

66 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) can abrogate the animal model ofmultiple sclerosis, experimental autoimmune encephalomyelitis (EAE), but whether this therapeutic effect occurs entirely through systemic immune modulation and whether CNS infiltration occurs after peripheral delivery are uncertain. We studied the clinical and neuropathologic effects of intravenously administered human MSCs (hMSCs) in C57BL/6 mice with EAE. Human MSCs significantly reduced the clinical disease severity, particularly in later disease. Large numbers of hMSCs migrated into gray and white matter at all levels of the spinal cord in both naive mice and mice with EAE. In the latter, hMSCs accumulated over time in demyelinated areas. There were 2 distinct morphological appearances of the hMSCs in the tissue, that is, rounded and less numerous process-bearing forms; very few expressed neural markers. The number of spinal cord white matter lesions and areas of white matter demyelination were reduced after hMSC treatment compared with control treatment. These findings show that central nervous system infiltration occurs after peripheral delivery of hMSCs, that they accumulate where there is myelin damage, and that they are associated with a reduced extent ofdemyelination. These data support a potential role for hMSCs in autologous cell therapy in multiple sclerosis.
Translated title of the contributionHuman mesenchymal stem cells infiltrate the spinal cord, reduce demyelination, and localize to white matter lesions in experimental autoimmune encephalomyelitis
Original languageEnglish
Pages (from-to)1087 - 1095
Number of pages9
JournalJournal of Neuropathology and Experimental Neurology
Volume69
Issue number11
DOIs
Publication statusPublished - Nov 2010

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