Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy

J Faber, CU Meyer, C Gemmer, A Russo, A Finn, C Murdoch, W Zenz, C Mannhalter, BU Zabel, H-J Schmitt, P Habermehl, F Zepp, M Knuf

Research output: Contribution to journalArticle (Academic Journal)peer-review

66 Citations (Scopus)

Abstract

Toll-like receptor 4 (TLR4) is required for efficient recognition of bacterial infections. We investigated an association between 2 TLR4 mutations (Asp299Gly and Thr399Ile) and meningococcal disease in 197 patients and 214 healthy controls by allele-specific real time polymerase chain reaction and direct sequencing. Although the allele frequency was not higher in the overall patient population, a significantly higher frequency in the 40 patients younger than 12 months of age (P = 0.007) was observed. We conclude that TLR4 mutations represent a risk factor for meningococcal disease in this age group.
Translated title of the contributionHuman toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy
Original languageEnglish
Pages (from-to)80 - 81
Number of pages2
JournalPediatric Infectious Disease Journal
Volume25 (1)
DOIs
Publication statusPublished - Jan 2006

Bibliographical note

Publisher: Lippincott, Williams & Wilkins

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