Toll-like receptor 4 (TLR4) is required for efficient recognition of bacterial infections. We investigated an association between 2 TLR4 mutations (Asp299Gly and Thr399Ile) and meningococcal disease in 197 patients and 214 healthy controls by allele-specific real time polymerase chain reaction and direct sequencing. Although the allele frequency was not higher in the overall patient population, a significantly higher frequency in the 40 patients younger than 12 months of age (P = 0.007) was observed. We conclude that TLR4 mutations represent a risk factor for meningococcal disease in this age group.
|Translated title of the contribution||Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy|
|Pages (from-to)||80 - 81|
|Number of pages||2|
|Journal||Pediatric Infectious Disease Journal|
|Publication status||Published - Jan 2006|