Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy

J Faber; CU Meyer; C Gemmer; A Russo; A Finn; C Murdoch; W Zenz; C Mannhalter; BU Zabel; H-J Schmitt; P Habermehl; F Zepp; M Knuf

doi:10.1097/01.inf.0000195595.22547.fe

Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy

J Faber, CU Meyer, C Gemmer, A Russo, A Finn, C Murdoch, W Zenz, C Mannhalter, BU Zabel, H-J Schmitt, P Habermehl, F Zepp, M Knuf

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Abstract

Toll-like receptor 4 (TLR4) is required for efficient recognition of bacterial infections. We investigated an association between 2 TLR4 mutations (Asp²⁹⁹Gly and Thr³⁹⁹Ile) and meningococcal disease in 197 patients and 214 healthy controls by allele-specific real time polymerase chain reaction and direct sequencing. Although the allele frequency was not higher in the overall patient population, a significantly higher frequency in the 40 patients younger than 12 months of age (P = 0.007) was observed. We conclude that TLR4 mutations represent a risk factor for meningococcal disease in this age group.

Translated title of the contribution	Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy
Original language	English
Pages (from-to)	80 - 81
Number of pages	2
Journal	Pediatric Infectious Disease Journal
Volume	25 (1)
DOIs	https://doi.org/10.1097/01.inf.0000195595.22547.fe
Publication status	Published - Jan 2006

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Publisher: Lippincott, Williams & Wilkins

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Faber, J., Meyer, CU., Gemmer, C., Russo, A., Finn, A., Murdoch, C., Zenz, W., Mannhalter, C., Zabel, BU., Schmitt, H.-J., Habermehl, P., Zepp, F., & Knuf, M. (2006). Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy. Pediatric Infectious Disease Journal, 25 (1), 80 - 81. https://doi.org/10.1097/01.inf.0000195595.22547.fe

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title = "Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy",

abstract = "Toll-like receptor 4 (TLR4) is required for efficient recognition of bacterial infections. We investigated an association between 2 TLR4 mutations (Asp299Gly and Thr399Ile) and meningococcal disease in 197 patients and 214 healthy controls by allele-specific real time polymerase chain reaction and direct sequencing. Although the allele frequency was not higher in the overall patient population, a significantly higher frequency in the 40 patients younger than 12 months of age (P = 0.007) was observed. We conclude that TLR4 mutations represent a risk factor for meningococcal disease in this age group.",

author = "J Faber and CU Meyer and C Gemmer and A Russo and A Finn and C Murdoch and W Zenz and C Mannhalter and BU Zabel and H-J Schmitt and P Habermehl and F Zepp and M Knuf",

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Faber, J, Meyer, CU, Gemmer, C, Russo, A, Finn, A, Murdoch, C, Zenz, W, Mannhalter, C, Zabel, BU, Schmitt, H-J, Habermehl, P, Zepp, F & Knuf, M 2006, 'Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy', Pediatric Infectious Disease Journal, vol. 25 (1), pp. 80 - 81. https://doi.org/10.1097/01.inf.0000195595.22547.fe

TY - JOUR

T1 - Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy

AU - Faber, J

AU - Meyer, CU

AU - Gemmer, C

AU - Russo, A

AU - Finn, A

AU - Murdoch, C

AU - Zenz, W

AU - Mannhalter, C

AU - Zabel, BU

AU - Schmitt, H-J

AU - Habermehl, P

AU - Zepp, F

AU - Knuf, M

N1 - Publisher: Lippincott, Williams & Wilkins

PY - 2006/1

Y1 - 2006/1

N2 - Toll-like receptor 4 (TLR4) is required for efficient recognition of bacterial infections. We investigated an association between 2 TLR4 mutations (Asp299Gly and Thr399Ile) and meningococcal disease in 197 patients and 214 healthy controls by allele-specific real time polymerase chain reaction and direct sequencing. Although the allele frequency was not higher in the overall patient population, a significantly higher frequency in the 40 patients younger than 12 months of age (P = 0.007) was observed. We conclude that TLR4 mutations represent a risk factor for meningococcal disease in this age group.

AB - Toll-like receptor 4 (TLR4) is required for efficient recognition of bacterial infections. We investigated an association between 2 TLR4 mutations (Asp299Gly and Thr399Ile) and meningococcal disease in 197 patients and 214 healthy controls by allele-specific real time polymerase chain reaction and direct sequencing. Although the allele frequency was not higher in the overall patient population, a significantly higher frequency in the 40 patients younger than 12 months of age (P = 0.007) was observed. We conclude that TLR4 mutations represent a risk factor for meningococcal disease in this age group.

U2 - 10.1097/01.inf.0000195595.22547.fe

DO - 10.1097/01.inf.0000195595.22547.fe

M3 - Article (Academic Journal)

SN - 1532-0987

VL - 25 (1)

SP - 80

EP - 81

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

ER -

Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy

Abstract

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