Abstract
Toll-like receptor 4 (TLR4) is required for efficient recognition of bacterial infections. We investigated an association between 2 TLR4 mutations (Asp299Gly and Thr399Ile) and meningococcal disease in 197 patients and 214 healthy controls by allele-specific real time polymerase chain reaction and direct sequencing. Although the allele frequency was not higher in the overall patient population, a significantly higher frequency in the 40 patients younger than 12 months of age (P = 0.007) was observed. We conclude that TLR4 mutations represent a risk factor for meningococcal disease in this age group.
Translated title of the contribution | Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy |
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Original language | English |
Pages (from-to) | 80 - 81 |
Number of pages | 2 |
Journal | Pediatric Infectious Disease Journal |
Volume | 25 (1) |
DOIs | |
Publication status | Published - Jan 2006 |