Human Tonsil-derived Dendritic Cells are Poor Inducers of T cell Immunity to Mucosally Encountered Pathogens

Claire M. Hallissey, Robert S. Heyderman, Neil A. Williams*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

7 Citations (Scopus)

Abstract

The mucosal immune system must initiate and regulate protective immunity, while balancing this immunity with tolerance to harmless antigens and bacterial commensals. We have explored the hypothesis that mucosal dendritic cells (DC) control the balance between regulation and immunity, by studying the responses of human tonsil-derived DC to Neisseria meningitidis as a model organism. We show that tonsil DC are able to sample their antigenic environment, internalizing Nm and expressing high levels of HLA-DR and CD86. However, in comparison to monocyte-derived DC (moDC), they respond to pathogen encounter with only low level cytokine production, largely dominated by TGF beta. Functionally, tonsil DC also only stimulated low levels of antigen-specific T cell proliferation and cytokine production when compared to moDC. We therefore propose that the default role for DC in the nasopharynx is to maintain tolerance/ignorance of the large volume of harmless antigens and bacterial commensals encountered at the nasopharyngeal mucosa.

Original languageEnglish
Pages (from-to)1847-1856
Number of pages10
JournalJournal of Infectious Diseases
Volume209
Issue number11
DOIs
Publication statusPublished - 1 Jun 2014

Keywords

  • Dendritic cells
  • mucosal immunity
  • Neisseria meningitidis
  • tolerance
  • tonsils
  • NEISSERIA-MENINGITIDIS
  • RESPIRATORY-TRACT
  • INTERLEUKIN-12 PRODUCTION
  • CYTOKINE PRODUCTION
  • EPITHELIAL-CELLS
  • BACTERIA
  • HOMEOSTASIS
  • DISEASE
  • POPULATIONS
  • ACTIVATION

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