Hybrid optimal scheduling for intermittent androgen suppression of prostate cancer

Y. Hirata; M Di Bernardo; N. Bruchovsky; K. Aihara

doi:10.1063/1.3526968

Hybrid optimal scheduling for intermittent androgen suppression of prostate cancer

Y. Hirata, M Di Bernardo, N. Bruchovsky, K. Aihara

Department of Engineering Mathematics

Research output: Contribution to journal › Article (Academic Journal) › peer-review

27 Citations (Scopus)

Abstract

We propose a method for achieving an optimal protocol of intermittent androgen suppression for the treatment of prostate cancer. Since the model that reproduces the dynamical behavior of the surrogate tumor marker, prostate specific antigen, is piecewise linear, we can obtain an analytical solution for the model. Based on this, we derive conditions for either stopping or delaying recurrent disease. The solution also provides a design principle for the most favorable schedule of treatment that minimizes the rate of expansion of the malignant cell population.

Translated title of the contribution	Hybrid optimal scheduling for intermittent androgen suppression of prostate cancer
Original language	English
Number of pages	10
Journal	Chaos
Volume	20 Issue 4
DOIs	https://doi.org/10.1063/1.3526968
Publication status	Published - 2011

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Engineering Mathematics Research Group

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http://chaos.aip.org/resource/1/chaoeh/v20/i4/p045125_s1

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title = "Hybrid optimal scheduling for intermittent androgen suppression of prostate cancer",

abstract = "We propose a method for achieving an optimal protocol of intermittent androgen suppression for the treatment of prostate cancer. Since the model that reproduces the dynamical behavior of the surrogate tumor marker, prostate specific antigen, is piecewise linear, we can obtain an analytical solution for the model. Based on this, we derive conditions for either stopping or delaying recurrent disease. The solution also provides a design principle for the most favorable schedule of treatment that minimizes the rate of expansion of the malignant cell population.",

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AU - Di Bernardo, M

AU - Bruchovsky, N.

AU - Aihara, K.

PY - 2011

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N2 - We propose a method for achieving an optimal protocol of intermittent androgen suppression for the treatment of prostate cancer. Since the model that reproduces the dynamical behavior of the surrogate tumor marker, prostate specific antigen, is piecewise linear, we can obtain an analytical solution for the model. Based on this, we derive conditions for either stopping or delaying recurrent disease. The solution also provides a design principle for the most favorable schedule of treatment that minimizes the rate of expansion of the malignant cell population.

AB - We propose a method for achieving an optimal protocol of intermittent androgen suppression for the treatment of prostate cancer. Since the model that reproduces the dynamical behavior of the surrogate tumor marker, prostate specific antigen, is piecewise linear, we can obtain an analytical solution for the model. Based on this, we derive conditions for either stopping or delaying recurrent disease. The solution also provides a design principle for the most favorable schedule of treatment that minimizes the rate of expansion of the malignant cell population.

U2 - 10.1063/1.3526968

DO - 10.1063/1.3526968

M3 - Article (Academic Journal)

C2 - 21198137

SN - 1089-7682

VL - 20 Issue 4

JO - Chaos

JF - Chaos

ER -

Hybrid optimal scheduling for intermittent androgen suppression of prostate cancer

Abstract

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UN SDGs

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