Hybrid optimal scheduling for intermittent androgen suppression of prostate cancer

Y. Hirata, M Di Bernardo, N. Bruchovsky, K. Aihara

Research output: Contribution to journalArticle (Academic Journal)peer-review

26 Citations (Scopus)

Abstract

We propose a method for achieving an optimal protocol of intermittent androgen suppression for the treatment of prostate cancer. Since the model that reproduces the dynamical behavior of the surrogate tumor marker, prostate specific antigen, is piecewise linear, we can obtain an analytical solution for the model. Based on this, we derive conditions for either stopping or delaying recurrent disease. The solution also provides a design principle for the most favorable schedule of treatment that minimizes the rate of expansion of the malignant cell population.
Translated title of the contributionHybrid optimal scheduling for intermittent androgen suppression of prostate cancer
Original languageEnglish
Number of pages10
JournalChaos
Volume20 Issue 4
DOIs
Publication statusPublished - 2011

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