Hydrogels as a Replacement Material for Damaged Articular Hyaline Cartilage

Charlotte M Beddoes, Michael R Whitehouse, Wuge H Briscoe, Bo Su*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

18 Citations (Scopus)
399 Downloads (Pure)

Abstract

Hyaline cartilage is a strong durable material that lubricates joint movement. Due to its avascular structure, cartilage has a poor self-healing ability, thus, a challenge in joint recovery. When severely damaged, cartilage may need to be replaced. However, currently we are unable to replicate the hyaline cartilage, and as such, alternative materials with considerably different properties are used. This results in undesirable side effects, including inadequate lubrication, wear debris, wear of the opposing articular cartilage, and weakening of the surrounding tissue. With the number of surgeries for cartilage repair increasing, a need for materials that can better mimic cartilage, and support the surrounding material in its typical function, is becoming evident. Here, we present a brief overview of the structure and properties of the hyaline cartilage and the current methods for cartilage repair. We then highlight some of the alternative materials under development as potential methods of repair; this is followed by an overview of the development of tough hydrogels. In particular, double network (DN) hydrogels are a promising replacement material, with continually improving physical properties. These hydrogels are coming closer to replicating the strength and toughness of the hyaline cartilage, while offering excellent lubrication. We conclude by highlighting several different methods of integrating replacement materials with the native joint to ensure stability and optimal behaviour.
Original languageEnglish
Article number443
Number of pages19
JournalMaterials
Volume9
Issue number6
Early online date3 Jun 2016
DOIs
Publication statusPublished - Jun 2016

Structured keywords

  • Centre for Surgical Research

Keywords

  • articular cartilage
  • hydrogels
  • self-healing
  • implant
  • double network

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