Hydroxyapatite/gelatin/gellan sponges as nanocomposite scaffolds for bone reconstruction

Niccoletta Barbani, Giulio D Guerra, Caterina Cristallini, Patrizia Urciuoli, Riccardo Avvisati, Alessandro Sala, Elisabetta Rosellini

Research output: Contribution to journalArticle (Academic Journal)peer-review

44 Citations (Scopus)


The aim of this work was the morphological, physicochemical, mechanical and biological characterization of a new composite system, based on gelatin, gellan and hydroxyapatite, and mimicking the composition of natural bone. Porous scaffolds were prepared by freeze-drying technique, under three different conditions of freezing. The morphological analysis showed a homogeneous porosity, with well interconnected pores, for the sample which underwent a more rapid freezing. The elastic modulus of the same sample was close to that of the natural bone. The presence of interactions among the components was demonstrated through the physicochemical investigation. In addition, the infrared chemical imaging analysis pointed out the similarity among the composite scaffold and the natural bone, in terms of chemical composition, homogeneity, molecular interactions and structural conformation. Preliminary biological characterization showed a good adhesion and proliferation of human mesenchymal stem cells.

Original languageEnglish
Pages (from-to)51-61
Number of pages11
JournalJournal of Materials Science: Materials in Medicine
Issue number1
Publication statusPublished - Jan 2012


  • Bone Development
  • Bone Substitutes
  • Calorimetry, Differential Scanning
  • Carbohydrate Sequence
  • Durapatite/chemistry
  • Freeze Drying
  • Gelatin/chemistry
  • Humans
  • Microscopy, Electron, Scanning
  • Molecular Sequence Data
  • Nanocomposites
  • Polysaccharides, Bacterial/chemistry
  • Spectroscopy, Fourier Transform Infrared


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