Hypertensive disorders of pregnancy, respiratory outcomes and atopy in childhood

Seif O Shaheen, Corrie Macdonald-Wallis, Debbie A Lawlor, A John Henderson

Research output: Contribution to journalArticle (Academic Journal)peer-review

18 Citations (Scopus)

Abstract

Few epidemiological studies have investigated the role of hypertensive disorders of pregnancy in the aetiology of childhood respiratory and atopic outcomes.In the Avon Longitudinal Study of Parents and Children we examined associations of maternal gestational hypertension, hypertension before pregnancy and pre-eclampsia with wheezing at 18 months, wheezing and asthma at 7 years and lung function at 8-9 years, after controlling for potential confounders (n=5322-8734, depending on outcome).Gestational hypertension was not associated with any of the outcomes. There was weak evidence for a positive association between pre-eclampsia and early wheezing (adjusted OR 1.31, 95% CI 0.94-1.82, compared to normotensive pregnancies) and for negative associations between pre-eclampsia and forced expiratory volume in 1 s (adjusted mean difference in sd score -0.14, 95% CI -0.33-0.06) and maximal mid-expiratory flow (-0.15, 95% CI -0.34-0.04). Hypertension before pregnancy was positively associated with wheezing (OR 1.63, 95% CI 1.16-2.31) and asthma (OR 1.34, 95% CI 1.00-1.79).Gestational hypertension is unlikely to be a risk factor for childhood respiratory disorders; hypertension before pregnancy may be a risk factor for childhood wheezing and asthma, but this finding needs replication. Larger studies are needed to confirm whether pre-eclampsia is associated with impaired childhood lung function.

Original languageEnglish
Pages (from-to)156-65
Number of pages10
JournalEuropean Respiratory Journal
Volume47
Issue number1
DOIs
Publication statusPublished - Jan 2016

Keywords

  • Asthma
  • Child
  • Female
  • Forced Expiratory Volume
  • Humans
  • Hypersensitivity, Immediate
  • Hypertension
  • Hypertension, Pregnancy-Induced
  • Infant
  • Longitudinal Studies
  • Male
  • Pre-Eclampsia
  • Pregnancy
  • Pregnancy Complications, Cardiovascular
  • Prenatal Exposure Delayed Effects
  • Respiratory Sounds
  • Risk Factors
  • United Kingdom
  • Journal Article

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