Hypoxic Pulmonary Vasoconstriction in Humans: Tale or Myth

A Hussain, M S Suleiman, S J George, M Loubani, A Morice

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

Hypoxic Pulmonary vasoconstriction (HPV) describes the physiological adaptive process of lungs to preserves systemic oxygenation. It has clinical implications in the development of pulmonary hypertension which impacts on outcomes of patients undergoing cardiothoracic surgery. This review examines both acute and chronic hypoxic vasoconstriction focusing on the distinct clinical implications and highlights the role of calcium and mitochondria in acute versus the role of reactive oxygen species and Rho GTPases in chronic HPV. Furthermore it identifies gaps of knowledge and need for further research in humans to clearly define this phenomenon and the underlying mechanism.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalOpen Cardiovascular Medicine Journal
Volume11
Early online date24 Jan 2017
DOIs
Publication statusPublished - Nov 2017

Keywords

  • Hypoxic Pulmonary Vasoconstriction
  • Acute hypoxia
  • Human
  • Chronic hypoxia
  • pulmonary hypertension

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