Hypoxic Pulmonary Vasoconstriction in Humans: Tale or Myth

A Hussain; M S Suleiman; S J George; M Loubani; A Morice

doi:10.2174/1874192401711010001

Hypoxic Pulmonary Vasoconstriction in Humans: Tale or Myth

A Hussain, M S Suleiman, S J George, M Loubani, A Morice

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Hypoxic Pulmonary vasoconstriction (HPV) describes the physiological adaptive process of lungs to preserves systemic oxygenation. It has clinical implications in the development of pulmonary hypertension which impacts on outcomes of patients undergoing cardiothoracic surgery. This review examines both acute and chronic hypoxic vasoconstriction focusing on the distinct clinical implications and highlights the role of calcium and mitochondria in acute versus the role of reactive oxygen species and Rho GTPases in chronic HPV. Furthermore it identifies gaps of knowledge and need for further research in humans to clearly define this phenomenon and the underlying mechanism.

Original language	English
Pages (from-to)	1-13
Number of pages	13
Journal	Open Cardiovascular Medicine Journal
Volume	11
Early online date	24 Jan 2017
DOIs	https://doi.org/10.2174/1874192401711010001
Publication status	Published - Nov 2017

Keywords

Hypoxic Pulmonary Vasoconstriction
Acute hypoxia
Human
Chronic hypoxia
pulmonary hypertension

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Final published version, 6.83 MBLicence: CC BY-NC

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AU - Hussain, A

AU - Suleiman, M S

AU - George, S J

AU - Loubani, M

AU - Morice, A

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AB - Hypoxic Pulmonary vasoconstriction (HPV) describes the physiological adaptive process of lungs to preserves systemic oxygenation. It has clinical implications in the development of pulmonary hypertension which impacts on outcomes of patients undergoing cardiothoracic surgery. This review examines both acute and chronic hypoxic vasoconstriction focusing on the distinct clinical implications and highlights the role of calcium and mitochondria in acute versus the role of reactive oxygen species and Rho GTPases in chronic HPV. Furthermore it identifies gaps of knowledge and need for further research in humans to clearly define this phenomenon and the underlying mechanism.

KW - Hypoxic Pulmonary Vasoconstriction

KW - Acute hypoxia

KW - Human

KW - Chronic hypoxia

KW - pulmonary hypertension

U2 - 10.2174/1874192401711010001

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JO - Open Cardiovascular Medicine Journal

JF - Open Cardiovascular Medicine Journal

ER -

Hypoxic Pulmonary Vasoconstriction in Humans: Tale or Myth

Abstract

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