Abstract
Objectives: There is growing interest in collecting outcome information directly from patients in clinical trials. This study evaluates what patients with rheumatic and musculoskeletal diseases (RMDs) consider important to know about symptomatic side effects they may experience from a new prescription drug.
Methods: Patients with inflammatory arthritis, who had one or more prescribed drugs for their disease for at least 12 months, participated in focus groups and individual interviews. Discussions were analysed using reflexive thematic analysis.
Results: We conducted seven focus groups with 34 participants across three continents. We found four overarching and two underpinning themes. The ‘impact on life’ was connected to participants’ ‘daily life’, ‘family life’, ‘work life’ and ‘social life’. In ‘psychological and physical aspects’ participants described ‘limitation to physical function’, ‘emotional dysregulation’ and ‘an overall mental state’. Extra tests, hospital visits and payment for medication were considered a ‘time, energy and financial burden’ of side effects. Participants explained important measurement issues to be ‘severity’, ‘frequency’ and ‘duration’. Underpinning these issues, participants evaluated the ‘benefit–harm balance’ which includes ‘the cumulative burden’ of having several side effects and the persistence of side effects over time.
Conclusions: In treatment for RMDs, there seems to be an urgent need for feasible measures of patient-reported bother (impact on life and cumulative burden) from side effects and the benefit–harm balance. These findings contribute new evidence in support of a target domain—an outcome that represents the patient voice evaluating the symptomatic treatment-related side effects for people with RMDs enrolled in clinical trials.
Methods: Patients with inflammatory arthritis, who had one or more prescribed drugs for their disease for at least 12 months, participated in focus groups and individual interviews. Discussions were analysed using reflexive thematic analysis.
Results: We conducted seven focus groups with 34 participants across three continents. We found four overarching and two underpinning themes. The ‘impact on life’ was connected to participants’ ‘daily life’, ‘family life’, ‘work life’ and ‘social life’. In ‘psychological and physical aspects’ participants described ‘limitation to physical function’, ‘emotional dysregulation’ and ‘an overall mental state’. Extra tests, hospital visits and payment for medication were considered a ‘time, energy and financial burden’ of side effects. Participants explained important measurement issues to be ‘severity’, ‘frequency’ and ‘duration’. Underpinning these issues, participants evaluated the ‘benefit–harm balance’ which includes ‘the cumulative burden’ of having several side effects and the persistence of side effects over time.
Conclusions: In treatment for RMDs, there seems to be an urgent need for feasible measures of patient-reported bother (impact on life and cumulative burden) from side effects and the benefit–harm balance. These findings contribute new evidence in support of a target domain—an outcome that represents the patient voice evaluating the symptomatic treatment-related side effects for people with RMDs enrolled in clinical trials.
| Original language | English |
|---|---|
| Article number | keae223 |
| Number of pages | 11 |
| Journal | Rheumatology |
| Early online date | 13 Apr 2024 |
| DOIs | |
| Publication status | E-pub ahead of print - 13 Apr 2024 |