De novo designed peptides for biological applications

AL Boyle, DN Woolfson

Research output: Contribution to journalArticle (Academic Journal)peer-review

129 Citations (Scopus)

Abstract

In recent years our ability to design and assemble peptide-based materials and objects de novo (i.e. from first principles) has improved considerably. This brings us to a point where the resulting assemblies are quite sophisticated and amenable to engineering in new functions. Whilst such systems could be used in a variety of ways, biological applications are of particular interest because of the demand for biocompatible, readily produced systems with potential as drug-delivery agents, components of biosensors and scaffolds for 3D cell and tissue culture. This tutorial review describes the building blocks (or tectons) that are being used in peptide assembly, highlights a range of materials and objects that have been produced, notably hydrogels and virus-like particles, and introduces a number of potential applications for the designs.
Translated title of the contributionDe novo designed peptides for biological applications
Original languageEnglish
Pages (from-to)4295 - 4306
Number of pages12
JournalChemical Society Reviews
Volume40
DOIs
Publication statusPublished - Mar 2011

Bibliographical note

Other: Tutorial Review. From themed issue: Small molecules in biology

Structured keywords

  • Bristol BioDesign Institute

Keywords

  • SYNTHETIC BIOLOGY

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