Identification of loci associated with schizophrenia by genome-wide association and follow-up

Michael Conlon O'Donovan, Nicholas John Craddock, Nadine Norton, Hywel John Williams, Timothy Rowan Peirce, Valentina Escott-Price, Ivan Nikolov, Marian Lindsay Hamshere, Liam Stuart Carroll, Lyudmila Georgieva, Sarah Lynne Dwyer, Peter Alan Holmans, Jonathan L Marchini, Chris C A Spencer, Bryan Howie, Hin-Tak Leung, Annette M Hartmann, Hans-Jürgen Möller, Derek W Morris, YongYong ShiGuoYin Feng, Per Hoffmann, Peter Propping, Catalina Vasilescu, Wolfgang Maier, Marcella Rietschel, Stanley Zammit, Johannes Schumacher, Emma M Quinn, Thomas G Schulze, Nigel Melville Williams, Ina Giegling, Nakao Iwata, Masashi Ikeda, Ariel Darvasi, Sagiv Shifman, Lin He, Jubao Duan, Alan R Sanders, Douglas F Levinson, Pablo V Gejman, Pablo V Gejman, Alan R Sanders, Jubao Duan, Douglas F Levinson, Nancy G Buccola, Bryan J Mowry, Robert Freedman, Farooq Amin, Donald W Black, Jeremy M Silverman, William F Byerley, C Robert Cloninger, Sven Cichon, Markus M Nöthen, Michael Gill, Aiden Corvin, Dan Rujescu, George Kirov, Michael John Owen

Research output: Contribution to journalArticle (Academic Journal)peer-review

868 Citations (Scopus)

Abstract

We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P <10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P <5 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 10-9).
Original languageEnglish
Pages (from-to)1053-1055
Number of pages3
JournalNature Genetics
Volume40
Issue number9
DOIs
Publication statusPublished - 1 Sep 2008

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