Identification of loci associated with schizophrenia by genome-wide association and follow-up

Michael Conlon O'Donovan, Nicholas John Craddock, Nadine Norton, Hywel John Williams, Timothy Rowan Peirce, Valentina Escott-Price, Ivan Nikolov, Marian Lindsay Hamshere, Liam Stuart Carroll, Lyudmila Georgieva, Sarah Lynne Dwyer, Peter Alan Holmans, Jonathan L Marchini, Chris C A Spencer, Bryan Howie, Hin-Tak Leung, Annette M Hartmann, Hans-Jürgen Möller, Derek W Morris, YongYong ShiGuoYin Feng, Per Hoffmann, Peter Propping, Catalina Vasilescu, Wolfgang Maier, Marcella Rietschel, Stanley Zammit, Johannes Schumacher, Emma M Quinn, Thomas G Schulze, Nigel Melville Williams, Ina Giegling, Nakao Iwata, Masashi Ikeda, Ariel Darvasi, Sagiv Shifman, Lin He, Jubao Duan, Alan R Sanders, Douglas F Levinson, Pablo V Gejman, Pablo V Gejman, Alan R Sanders, Jubao Duan, Douglas F Levinson, Nancy G Buccola, Bryan J Mowry, Robert Freedman, Farooq Amin, Donald W Black, Jeremy M Silverman, William F Byerley, C Robert Cloninger, Sven Cichon, Markus M Nöthen, Michael Gill, Aiden Corvin, Dan Rujescu, George Kirov, Michael John Owen

Research output: Contribution to journalArticle (Academic Journal)

840 Citations (Scopus)

Abstract

We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P <10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P <5 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 10-9).
Original languageEnglish
Pages (from-to)1053-1055
Number of pages3
JournalNature Genetics
Volume40
Issue number9
DOIs
Publication statusPublished - 1 Sep 2008

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    O'Donovan, M. C., Craddock, N. J., Norton, N., Williams, H. J., Peirce, T. R., Escott-Price, V., Nikolov, I., Hamshere, M. L., Carroll, L. S., Georgieva, L., Dwyer, S. L., Holmans, P. A., Marchini, J. L., Spencer, C. C. A., Howie, B., Leung, H-T., Hartmann, A. M., Möller, H-J., Morris, D. W., ... Owen, M. J. (2008). Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics, 40(9), 1053-1055. https://doi.org/10.1038/ng.201