Identification of loci associated with schizophrenia by genome-wide association and follow-up

Michael Conlon O'Donovan; Nicholas John Craddock; Nadine Norton; Hywel John Williams; Timothy Rowan Peirce; Valentina Escott-Price; Ivan Nikolov; Marian Lindsay Hamshere; Liam Stuart Carroll; Lyudmila Georgieva; Sarah Lynne Dwyer; Peter Alan Holmans; Jonathan L Marchini; Chris C A Spencer; Bryan Howie; Hin-Tak Leung; Annette M Hartmann; Hans-Jürgen Möller; Derek W Morris; YongYong Shi; GuoYin Feng; Per Hoffmann; Peter Propping; Catalina Vasilescu; Wolfgang Maier; Marcella Rietschel; Stanley Zammit; Johannes Schumacher; Emma M Quinn; Thomas G Schulze; Nigel Melville Williams; Ina Giegling; Nakao Iwata; Masashi Ikeda; Ariel Darvasi; Sagiv Shifman; Lin He; Jubao Duan; Alan R Sanders; Douglas F Levinson; Pablo V Gejman; Pablo V Gejman; Alan R Sanders; Jubao Duan; Douglas F Levinson; Nancy G Buccola; Bryan J Mowry; Robert Freedman; Farooq Amin; Donald W Black; Jeremy M Silverman; William F Byerley; C Robert Cloninger; Sven Cichon; Markus M Nöthen; Michael Gill; Aiden Corvin; Dan Rujescu; George Kirov; Michael John Owen

doi:10.1038/ng.201

Identification of loci associated with schizophrenia by genome-wide association and follow-up

Michael Conlon O'Donovan, Nicholas John Craddock, Nadine Norton, Hywel John Williams, Timothy Rowan Peirce, Valentina Escott-Price, Ivan Nikolov, Marian Lindsay Hamshere, Liam Stuart Carroll, Lyudmila Georgieva, Sarah Lynne Dwyer, Peter Alan Holmans, Jonathan L Marchini, Chris C A Spencer, Bryan Howie, Hin-Tak Leung, Annette M Hartmann, Hans-Jürgen Möller, Derek W Morris, YongYong ShiGuoYin Feng, Per Hoffmann, Peter Propping, Catalina Vasilescu, Wolfgang Maier, Marcella Rietschel, Stanley Zammit, Johannes Schumacher, Emma M Quinn, Thomas G Schulze, Nigel Melville Williams, Ina Giegling, Nakao Iwata, Masashi Ikeda, Ariel Darvasi, Sagiv Shifman, Lin He, Jubao Duan, Alan R Sanders, Douglas F Levinson, Pablo V Gejman, Pablo V Gejman, Alan R Sanders, Jubao Duan, Douglas F Levinson, Nancy G Buccola, Bryan J Mowry, Robert Freedman, Farooq Amin, Donald W Black, Jeremy M Silverman, William F Byerley, C Robert Cloninger, Sven Cichon, Markus M Nöthen, Michael Gill, Aiden Corvin, Dan Rujescu, George Kirov, Michael John Owen

Research output: Contribution to journal › Article (Academic Journal) › peer-review

963 Citations (Scopus)

Abstract

We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P <10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P <5 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 10-9).

Original language	English
Pages (from-to)	1053-1055
Number of pages	3
Journal	Nature Genetics
Volume	40
Issue number	9
DOIs	https://doi.org/10.1038/ng.201
Publication status	Published - 1 Sept 2008

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O'Donovan, M. C., Craddock, N. J., Norton, N., Williams, H. J., Peirce, T. R., Escott-Price, V., Nikolov, I., Hamshere, M. L., Carroll, L. S., Georgieva, L., Dwyer, S. L., Holmans, P. A., Marchini, J. L., Spencer, C. C. A., Howie, B., Leung, H.-T., Hartmann, A. M., Möller, H.-J., Morris, D. W., ... Owen, M. J. (2008). Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics, 40(9), 1053-1055. https://doi.org/10.1038/ng.201

@article{ef71072ffc26485394085ad0cdef1522,

title = "Identification of loci associated with schizophrenia by genome-wide association and follow-up",

abstract = "We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P <10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P <5 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 10-9).",

author = "O'Donovan, \{Michael Conlon\} and Craddock, \{Nicholas John\} and Nadine Norton and Williams, \{Hywel John\} and Peirce, \{Timothy Rowan\} and Valentina Escott-Price and Ivan Nikolov and Hamshere, \{Marian Lindsay\} and Carroll, \{Liam Stuart\} and Lyudmila Georgieva and Dwyer, \{Sarah Lynne\} and Holmans, \{Peter Alan\} and Marchini, \{Jonathan L\} and Spencer, \{Chris C A\} and Bryan Howie and Hin-Tak Leung and Hartmann, \{Annette M\} and Hans-J{\"u}rgen M{\"o}ller and Morris, \{Derek W\} and YongYong Shi and GuoYin Feng and Per Hoffmann and Peter Propping and Catalina Vasilescu and Wolfgang Maier and Marcella Rietschel and Stanley Zammit and Johannes Schumacher and Quinn, \{Emma M\} and Schulze, \{Thomas G\} and Williams, \{Nigel Melville\} and Ina Giegling and Nakao Iwata and Masashi Ikeda and Ariel Darvasi and Sagiv Shifman and Lin He and Jubao Duan and Sanders, \{Alan R\} and Levinson, \{Douglas F\} and Gejman, \{Pablo V\} and Gejman, \{Pablo V\} and Sanders, \{Alan R\} and Jubao Duan and Levinson, \{Douglas F\} and Buccola, \{Nancy G\} and Mowry, \{Bryan J\} and Robert Freedman and Farooq Amin and Black, \{Donald W\} and Silverman, \{Jeremy M\} and Byerley, \{William F\} and Cloninger, \{C Robert\} and Sven Cichon and N{\"o}then, \{Markus M\} and Michael Gill and Aiden Corvin and Dan Rujescu and George Kirov and Owen, \{Michael John\}",

year = "2008",

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day = "1",

doi = "10.1038/ng.201",

language = "English",

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journal = "Nature Genetics",

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O'Donovan, MC, Craddock, NJ, Norton, N, Williams, HJ, Peirce, TR, Escott-Price, V, Nikolov, I, Hamshere, ML, Carroll, LS, Georgieva, L, Dwyer, SL, Holmans, PA, Marchini, JL, Spencer, CCA, Howie, B, Leung, H-T, Hartmann, AM, Möller, H-J, Morris, DW, Shi, Y, Feng, G, Hoffmann, P, Propping, P, Vasilescu, C, Maier, W, Rietschel, M, Zammit, S, Schumacher, J, Quinn, EM, Schulze, TG, Williams, NM, Giegling, I, Iwata, N, Ikeda, M, Darvasi, A, Shifman, S, He, L, Duan, J, Sanders, AR, Levinson, DF, Gejman, PV, Gejman, PV, Sanders, AR, Duan, J, Levinson, DF, Buccola, NG, Mowry, BJ, Freedman, R, Amin, F, Black, DW, Silverman, JM, Byerley, WF, Cloninger, CR, Cichon, S, Nöthen, MM, Gill, M, Corvin, A, Rujescu, D, Kirov, G & Owen, MJ 2008, 'Identification of loci associated with schizophrenia by genome-wide association and follow-up', Nature Genetics, vol. 40, no. 9, pp. 1053-1055. https://doi.org/10.1038/ng.201

TY - JOUR

T1 - Identification of loci associated with schizophrenia by genome-wide association and follow-up

AU - O'Donovan, Michael Conlon

AU - Craddock, Nicholas John

AU - Norton, Nadine

AU - Williams, Hywel John

AU - Peirce, Timothy Rowan

AU - Escott-Price, Valentina

AU - Nikolov, Ivan

AU - Hamshere, Marian Lindsay

AU - Carroll, Liam Stuart

AU - Georgieva, Lyudmila

AU - Dwyer, Sarah Lynne

AU - Holmans, Peter Alan

AU - Marchini, Jonathan L

AU - Spencer, Chris C A

AU - Howie, Bryan

AU - Leung, Hin-Tak

AU - Hartmann, Annette M

AU - Möller, Hans-Jürgen

AU - Morris, Derek W

AU - Shi, YongYong

AU - Feng, GuoYin

AU - Hoffmann, Per

AU - Propping, Peter

AU - Vasilescu, Catalina

AU - Maier, Wolfgang

AU - Rietschel, Marcella

AU - Zammit, Stanley

AU - Schumacher, Johannes

AU - Quinn, Emma M

AU - Schulze, Thomas G

AU - Williams, Nigel Melville

AU - Giegling, Ina

AU - Iwata, Nakao

AU - Ikeda, Masashi

AU - Darvasi, Ariel

AU - Shifman, Sagiv

AU - He, Lin

AU - Duan, Jubao

AU - Sanders, Alan R

AU - Levinson, Douglas F

AU - Gejman, Pablo V

AU - Sanders, Alan R

AU - Duan, Jubao

AU - Levinson, Douglas F

AU - Buccola, Nancy G

AU - Mowry, Bryan J

AU - Freedman, Robert

AU - Amin, Farooq

AU - Black, Donald W

AU - Silverman, Jeremy M

AU - Byerley, William F

AU - Cloninger, C Robert

AU - Cichon, Sven

AU - Nöthen, Markus M

AU - Gill, Michael

AU - Corvin, Aiden

AU - Rujescu, Dan

AU - Kirov, George

AU - Owen, Michael John

PY - 2008/9/1

Y1 - 2008/9/1

N2 - We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P <10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P <5 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 10-9).

AB - We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P <10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P <5 10-4), and the overall pattern of replication was unlikely to occur by chance (P = 9 10-8). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 10-7) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 10-9).

U2 - 10.1038/ng.201

DO - 10.1038/ng.201

M3 - Article (Academic Journal)

C2 - 18677311

SN - 1061-4036

VL - 40

SP - 1053

EP - 1055

JO - Nature Genetics

JF - Nature Genetics

IS - 9

ER -

Identification of loci associated with schizophrenia by genome-wide association and follow-up

Abstract

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