Identifying a novel locus for psoriatic arthritis

Ashley Budu-Aggrey; John Bowes; Anne Barton

doi:10.1093/rheumatology/kev273

Identifying a novel locus for psoriatic arthritis

Ashley Budu-Aggrey, John Bowes, Anne Barton

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

15 Citations (Scopus)

Abstract

A number of studies have identified genetic risk loci for PsA, the majority of which also confer risk for psoriasis. The stronger heritability of PsA in comparison with psoriasis suggests that there should be risk loci that are specific for PsA. Identifying such loci could potentially inform therapy development to provide more effective treatments for PsA patients, especially with a considerable proportion being non-responsive to current therapies. Evidence of a PsA-specific locus has been previously found at HLA-B27 within the MHC region. A recent study has provided evidence of non-HLA risk loci that are specific for PsA at IL23R, PTPN22 and on chromosome 5q31. Functional characterization of these loci will provide further understanding of the pathways underlying PsA, and enable us to apply genetic findings for patient benefit.

Original language	English
Pages (from-to)	25-32
Number of pages	8
Journal	Rheumatology
Volume	55
Issue number	1
DOIs	https://doi.org/10.1093/rheumatology/kev273
Publication status	Published - 1 Jan 2016

Keywords

Arthritis, Psoriatic
DNA
Genetic Predisposition to Disease
Genome-Wide Association Study
HLA-B27 Antigen
Humans
Polymorphism, Single Nucleotide
Protein Tyrosine Phosphatase, Non-Receptor Type 22
Journal Article
Research Support, Non-U.S. Gov't
Review

Access to Document

10.1093/rheumatology/kev273

Handle.net

Persistent link

Cite this

@article{13799ecec73a460f8ca79547d917a429,

title = "Identifying a novel locus for psoriatic arthritis",

abstract = "A number of studies have identified genetic risk loci for PsA, the majority of which also confer risk for psoriasis. The stronger heritability of PsA in comparison with psoriasis suggests that there should be risk loci that are specific for PsA. Identifying such loci could potentially inform therapy development to provide more effective treatments for PsA patients, especially with a considerable proportion being non-responsive to current therapies. Evidence of a PsA-specific locus has been previously found at HLA-B27 within the MHC region. A recent study has provided evidence of non-HLA risk loci that are specific for PsA at IL23R, PTPN22 and on chromosome 5q31. Functional characterization of these loci will provide further understanding of the pathways underlying PsA, and enable us to apply genetic findings for patient benefit.",

keywords = "Arthritis, Psoriatic, DNA, Genetic Predisposition to Disease, Genome-Wide Association Study, HLA-B27 Antigen, Humans, Polymorphism, Single Nucleotide, Protein Tyrosine Phosphatase, Non-Receptor Type 22, Journal Article, Research Support, Non-U.S. Gov't, Review",

author = "Ashley Budu-Aggrey and John Bowes and Anne Barton",

note = "{\textcopyright} The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology.",

year = "2016",

month = jan,

day = "1",

doi = "10.1093/rheumatology/kev273",

language = "English",

volume = "55",

pages = "25--32",

journal = "Rheumatology",

issn = "1462-0324",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - Identifying a novel locus for psoriatic arthritis

AU - Budu-Aggrey, Ashley

AU - Bowes, John

AU - Barton, Anne

N1 - © The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - A number of studies have identified genetic risk loci for PsA, the majority of which also confer risk for psoriasis. The stronger heritability of PsA in comparison with psoriasis suggests that there should be risk loci that are specific for PsA. Identifying such loci could potentially inform therapy development to provide more effective treatments for PsA patients, especially with a considerable proportion being non-responsive to current therapies. Evidence of a PsA-specific locus has been previously found at HLA-B27 within the MHC region. A recent study has provided evidence of non-HLA risk loci that are specific for PsA at IL23R, PTPN22 and on chromosome 5q31. Functional characterization of these loci will provide further understanding of the pathways underlying PsA, and enable us to apply genetic findings for patient benefit.

AB - A number of studies have identified genetic risk loci for PsA, the majority of which also confer risk for psoriasis. The stronger heritability of PsA in comparison with psoriasis suggests that there should be risk loci that are specific for PsA. Identifying such loci could potentially inform therapy development to provide more effective treatments for PsA patients, especially with a considerable proportion being non-responsive to current therapies. Evidence of a PsA-specific locus has been previously found at HLA-B27 within the MHC region. A recent study has provided evidence of non-HLA risk loci that are specific for PsA at IL23R, PTPN22 and on chromosome 5q31. Functional characterization of these loci will provide further understanding of the pathways underlying PsA, and enable us to apply genetic findings for patient benefit.

KW - Arthritis, Psoriatic

KW - DNA

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - HLA-B27 Antigen

KW - Humans

KW - Polymorphism, Single Nucleotide

KW - Protein Tyrosine Phosphatase, Non-Receptor Type 22

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1093/rheumatology/kev273

DO - 10.1093/rheumatology/kev273

M3 - Review article (Academic Journal)

C2 - 26255310

SN - 1462-0324

VL - 55

SP - 25

EP - 32

JO - Rheumatology

JF - Rheumatology

IS - 1

ER -

Identifying a novel locus for psoriatic arthritis

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Cite this