Identifying and Validating New Drug Targets for Stroke and Beyond

Andrew Plump, George Davey Smith

Research output: Contribution to journalEditorial (Academic Journal)peer-review

2 Citations (Scopus)
115 Downloads (Pure)

Abstract

Until very recently, drug discovery attrition rates have been increasing.1 This poor return on investment in biopharmaceutical research and development can be explained by scientific and extrascientific influences. Regulatory, payer, and commercial forces incentivized pharmaceutical companies to focus on common diseases and incremental improvements on existing mechanisms. The majority of resources within pharmaceutical companies have traditionally been focused on small-molecule drug discovery programs, reflecting a “hammer and a nail” mindset, with small-molecule chemistry as the hammer and the nail a classically defined “druggable” target. Rather than starting with a target based on strong human biological rationale, targets have been selected based on their ability to be “drugged” by a medicinal chemist. Compounding this problem has been an inadequate understanding of disease biology and an overreliance on animal models of human disease.
Original languageEnglish
Pages (from-to)831-835
Number of pages5
JournalCirculation
Volume140
Issue number10
DOIs
Publication statusPublished - 3 Sep 2019

Keywords

  • Editorials
  • drug discovery
  • Mendelian randomization analysis
  • stroke

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