Identifying palladium culprits in amine catalysis

Mickaël Avanthay; Robin B. Bedford; Callum S. Begg; Dietrich Böse; Jonathan Clayden; Sean A. Davis; Jean Charles Eloi; Georgy P. Goryunov; Ingo V. Hartung; Joseph Heeley; Kirill A. Khaikin; Matthew O. Kitching; Johannes Krieger; Pavel S. Kulyabin; Alastair J.J. Lennox; Roberto Nolla-Saltiel; Natalie E. Pridmore; Benjamin J.S. Rowsell; Hazel A. Sparkes; Dmitry V. Uborsky; Alexander Z. Voskoboynikov; Mark P. Walsh; Harry J. Wilkinson

doi:10.1038/s41929-021-00710-1

Identifying palladium culprits in amine catalysis

Mickaël Avanthay, Robin B. Bedford^*, Callum S. Begg, Dietrich Böse, Jonathan Clayden^*, Sean A. Davis, Jean Charles Eloi, Georgy P. Goryunov^*, Ingo V. Hartung^*, Joseph Heeley, Kirill A. Khaikin, Matthew O. Kitching^*, Johannes Krieger, Pavel S. Kulyabin, Alastair J.J. Lennox^*, Roberto Nolla-Saltiel, Natalie E. Pridmore, Benjamin J.S. Rowsell, Hazel A. Sparkes, Dmitry V. UborskyAlexander Z. Voskoboynikov, Mark P. Walsh, Harry J. Wilkinson

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Original language	English
Pages (from-to)	994-998
Number of pages	5
Journal	Nature Catalysis
Volume	4
DOIs	https://doi.org/10.1038/s41929-021-00710-1
Publication status	Published - 2 Dec 2021

Bibliographical note

Funding Information:
We thank S. Traxel and his team (Merck Element Analytics) for conducting and evaluating the ICP–MS analysis of 1a, D. S. Yufit (Durham) for the structure determination of 1a, A. N. Iashin for conducting NMR experiments (Moscow) and M. I. Sharikov for fruitful discussions. We thank the Chemical Synthesis Centre for Doctoral Training (funded by EPSRC (EP/L015366/1), AstraZeneca, GlaxoSmithKline, Syngenta, UCB, Ziylo and the University of Bristol) for the provision of a PhD studentship (B.J.S.R.); the Technology Enhanced Chemical Synthesis Centre for Doctoral Training (funded by EPSRC (EP/S024107/1), AstraZeneca, Astex, Bayer, GlaxoSmithKline, Syngenta, Vertex and the University of Bristol) for the provision of a PhD studentship (J.H.); GSK (iCASE studentship to M.A.); the EPSRC (PhD studentship to C.S.B., EP/ T518001/1, project reference 2456710); the UK Catalysis Hub (support provided to R.B.B., A.J.J.L. and R.N.-S. for membership of the UK Catalysis Hub Consortium, funded by EPSRC grants EP/R027129/1 and EP/S018050/1)); the ERC (Advanced Grant 883786 to J.C.) and the Royal Society (University Research Fellowship to A.J.J.L.; Research Fellowship to M.O.K. (UF150536) and equipment grant (RGS\R2\180467)).

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Avanthay, M., Bedford, R. B., Begg, C. S., Böse, D., Clayden, J., Davis, S. A., Eloi, J. C., Goryunov, G. P., Hartung, I. V., Heeley, J., Khaikin, K. A., Kitching, M. O., Krieger, J., Kulyabin, P. S., Lennox, A. J. J., Nolla-Saltiel, R., Pridmore, N. E., Rowsell, B. J. S., Sparkes, H. A., ... Wilkinson, H. J. (2021). Identifying palladium culprits in amine catalysis. Nature Catalysis, 4, 994-998. https://doi.org/10.1038/s41929-021-00710-1

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title = "Identifying palladium culprits in amine catalysis",

author = "Micka{\"e}l Avanthay and Bedford, {Robin B.} and Begg, {Callum S.} and Dietrich B{\"o}se and Jonathan Clayden and Davis, {Sean A.} and Eloi, {Jean Charles} and Goryunov, {Georgy P.} and Hartung, {Ingo V.} and Joseph Heeley and Khaikin, {Kirill A.} and Kitching, {Matthew O.} and Johannes Krieger and Kulyabin, {Pavel S.} and Lennox, {Alastair J.J.} and Roberto Nolla-Saltiel and Pridmore, {Natalie E.} and Rowsell, {Benjamin J.S.} and Sparkes, {Hazel A.} and Uborsky, {Dmitry V.} and Voskoboynikov, {Alexander Z.} and Walsh, {Mark P.} and Wilkinson, {Harry J.}",

note = "Funding Information: We thank S. Traxel and his team (Merck Element Analytics) for conducting and evaluating the ICP–MS analysis of 1a, D. S. Yufit (Durham) for the structure determination of 1a, A. N. Iashin for conducting NMR experiments (Moscow) and M. I. Sharikov for fruitful discussions. We thank the Chemical Synthesis Centre for Doctoral Training (funded by EPSRC (EP/L015366/1), AstraZeneca, GlaxoSmithKline, Syngenta, UCB, Ziylo and the University of Bristol) for the provision of a PhD studentship (B.J.S.R.); the Technology Enhanced Chemical Synthesis Centre for Doctoral Training (funded by EPSRC (EP/S024107/1), AstraZeneca, Astex, Bayer, GlaxoSmithKline, Syngenta, Vertex and the University of Bristol) for the provision of a PhD studentship (J.H.); GSK (iCASE studentship to M.A.); the EPSRC (PhD studentship to C.S.B., EP/ T518001/1, project reference 2456710); the UK Catalysis Hub (support provided to R.B.B., A.J.J.L. and R.N.-S. for membership of the UK Catalysis Hub Consortium, funded by EPSRC grants EP/R027129/1 and EP/S018050/1)); the ERC (Advanced Grant 883786 to J.C.) and the Royal Society (University Research Fellowship to A.J.J.L.; Research Fellowship to M.O.K. (UF150536) and equipment grant (RGS\R2\180467)).",

year = "2021",

month = dec,

day = "2",

doi = "10.1038/s41929-021-00710-1",

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Avanthay, M , Bedford, RB, Begg, CS, Böse, D, Clayden, J , Davis, SA, Eloi, JC, Goryunov, GP, Hartung, IV, Heeley, J, Khaikin, KA, Kitching, MO, Krieger, J, Kulyabin, PS, Lennox, AJJ, Nolla-Saltiel, R, Pridmore, NE, Rowsell, BJS, Sparkes, HA, Uborsky, DV, Voskoboynikov, AZ, Walsh, MP & Wilkinson, HJ 2021, 'Identifying palladium culprits in amine catalysis', Nature Catalysis, vol. 4, pp. 994-998. https://doi.org/10.1038/s41929-021-00710-1

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T1 - Identifying palladium culprits in amine catalysis

AU - Avanthay, Mickaël

AU - Bedford, Robin B.

AU - Begg, Callum S.

AU - Böse, Dietrich

AU - Clayden, Jonathan

AU - Davis, Sean A.

AU - Eloi, Jean Charles

AU - Goryunov, Georgy P.

AU - Hartung, Ingo V.

AU - Heeley, Joseph

AU - Khaikin, Kirill A.

AU - Kitching, Matthew O.

AU - Krieger, Johannes

AU - Kulyabin, Pavel S.

AU - Lennox, Alastair J.J.

AU - Nolla-Saltiel, Roberto

AU - Pridmore, Natalie E.

AU - Rowsell, Benjamin J.S.

AU - Sparkes, Hazel A.

AU - Uborsky, Dmitry V.

AU - Voskoboynikov, Alexander Z.

AU - Walsh, Mark P.

AU - Wilkinson, Harry J.

N1 - Funding Information: We thank S. Traxel and his team (Merck Element Analytics) for conducting and evaluating the ICP–MS analysis of 1a, D. S. Yufit (Durham) for the structure determination of 1a, A. N. Iashin for conducting NMR experiments (Moscow) and M. I. Sharikov for fruitful discussions. We thank the Chemical Synthesis Centre for Doctoral Training (funded by EPSRC (EP/L015366/1), AstraZeneca, GlaxoSmithKline, Syngenta, UCB, Ziylo and the University of Bristol) for the provision of a PhD studentship (B.J.S.R.); the Technology Enhanced Chemical Synthesis Centre for Doctoral Training (funded by EPSRC (EP/S024107/1), AstraZeneca, Astex, Bayer, GlaxoSmithKline, Syngenta, Vertex and the University of Bristol) for the provision of a PhD studentship (J.H.); GSK (iCASE studentship to M.A.); the EPSRC (PhD studentship to C.S.B., EP/ T518001/1, project reference 2456710); the UK Catalysis Hub (support provided to R.B.B., A.J.J.L. and R.N.-S. for membership of the UK Catalysis Hub Consortium, funded by EPSRC grants EP/R027129/1 and EP/S018050/1)); the ERC (Advanced Grant 883786 to J.C.) and the Royal Society (University Research Fellowship to A.J.J.L.; Research Fellowship to M.O.K. (UF150536) and equipment grant (RGS\R2\180467)).

PY - 2021/12/2

Y1 - 2021/12/2

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U2 - 10.1038/s41929-021-00710-1

DO - 10.1038/s41929-021-00710-1

M3 - Article (Academic Journal)

SN - 2520-1158

VL - 4

SP - 994

EP - 998

JO - Nature Catalysis

JF - Nature Catalysis

ER -

Identifying palladium culprits in amine catalysis

Bibliographical note

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