Identifying research priorities in breast cancer surgery: a UK priority setting partnership with the James Lind Alliance

Shelley Potter; Katherine Fairhurst; Katherine Cowan; Simon Vincent; Ian Lewis; Ramsey I Cutress; Hilary Stobart; Patricia Fairbrother; Sophia Turner; Kayleigh Davies-Crowley; Ranjeet Jeevan; Tim Rattay; Rachel O'Connell; Nigel Bundred; Stuart A McIntosh

doi:10.1007/s10549-022-06756-4

Identifying research priorities in breast cancer surgery: a UK priority setting partnership with the James Lind Alliance

Shelley Potter^*, Katherine Fairhurst, Katherine Cowan, Simon Vincent, Ian Lewis, Ramsey I Cutress, Hilary Stobart, Patricia Fairbrother, Sophia Turner, Kayleigh Davies-Crowley, Ranjeet Jeevan, Tim Rattay, Rachel O'Connell, Nigel Bundred, Stuart A McIntosh^*

^*Corresponding author for this work

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Abstract

PURPOSE: A James Lind Alliance priority setting partnership was developed to identify research priorities in breast cancer surgery from individuals with lived experience, at high genetic risk of breast cancer, and healthcare professionals (HCPs).

METHODS: 'Uncertainties' were collected using an online survey. Following an evidence check and development of summary questions, an interim survey asked participants to rank their top 10 research priorities from the question list. Top-ranked questions from patient/carer, high-risk and professional groups were carried forward for discussion to a final online prioritisation workshop.

RESULTS: 260 participants (101 patients/carers, 156 HCPs) submitted 940 uncertainties via the initial survey. These were analysed thematically into 128 summary questions in six topic areas. Following evidence checking, 59 questions were included in the interim survey which was completed by 572 respondents. Marked differences were seen in questions prioritised by patients/carers, HCPs and women at high-risk. The top eight priorities in patient/carer and professional groups and top two priorities for high-risk women were carried forward to the online workshop at which 22 participants discussed and agreed the final top 10. Key themes included de-escalation of breast and axillary surgery, factors impacting the development/detection of locoregional recurrence and optimal provision of support for informed treatment decision-making.

CONCLUSION: The top 10 research priorities in breast cancer surgery have been agreed. However, the observed differences in research priorities identified by patients and professional groups were not anticipated. Top priorities from both groups should inform future UK breast cancer surgical research, to ensure that it addresses questions that are important to breast cancer community as a whole.

Original language	English
Pages (from-to)	39-49
Number of pages	11
Journal	Breast Cancer Research and Treatment
Volume	197
Issue number	1
Early online date	1 Nov 2022
DOIs	https://doi.org/10.1007/s10549-022-06756-4
Publication status	Published - 1 Jan 2023

Bibliographical note

Funding Information:
This work was funded by the Association of Breast Surgery. Shelley Potter is an NIHR Clinician Scientist (CS-2016–16-019), Katherine Fairhurst and Tim Rattay are NIHR Clinical Lecturers. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health and Care Research or the Department of Health and Social Care.

Publisher Copyright:
© 2022, The Author(s).

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12 Citations
1 Article (Academic Journal)

Identifying research priorities for improving information and support for patients undergoing breast cancer surgery: a UK patient-centred priority setting project
Johnston, E., Cowan, K., MacKenzie, M., Patton, S., Turner, L., Fairbrother, P., McIntosh, S. A. & Potter, S., 24 Jun 2024, (E-pub ahead of print) In: Breast Cancer Research and Treatment. 208, 1, p. 215-222 8 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review

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3 Citations (Scopus)

Cite this

Potter, S., Fairhurst, K., Cowan, K., Vincent, S., Lewis, I., Cutress, R. I., Stobart, H., Fairbrother, P., Turner, S., Davies-Crowley, K., Jeevan, R., Rattay, T., O'Connell, R., Bundred, N., & McIntosh, S. A. (2023). Identifying research priorities in breast cancer surgery: a UK priority setting partnership with the James Lind Alliance. Breast Cancer Research and Treatment, 197(1), 39-49. https://doi.org/10.1007/s10549-022-06756-4

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abstract = "PURPOSE: A James Lind Alliance priority setting partnership was developed to identify research priorities in breast cancer surgery from individuals with lived experience, at high genetic risk of breast cancer, and healthcare professionals (HCPs).METHODS: 'Uncertainties' were collected using an online survey. Following an evidence check and development of summary questions, an interim survey asked participants to rank their top 10 research priorities from the question list. Top-ranked questions from patient/carer, high-risk and professional groups were carried forward for discussion to a final online prioritisation workshop.RESULTS: 260 participants (101 patients/carers, 156 HCPs) submitted 940 uncertainties via the initial survey. These were analysed thematically into 128 summary questions in six topic areas. Following evidence checking, 59 questions were included in the interim survey which was completed by 572 respondents. Marked differences were seen in questions prioritised by patients/carers, HCPs and women at high-risk. The top eight priorities in patient/carer and professional groups and top two priorities for high-risk women were carried forward to the online workshop at which 22 participants discussed and agreed the final top 10. Key themes included de-escalation of breast and axillary surgery, factors impacting the development/detection of locoregional recurrence and optimal provision of support for informed treatment decision-making.CONCLUSION: The top 10 research priorities in breast cancer surgery have been agreed. However, the observed differences in research priorities identified by patients and professional groups were not anticipated. Top priorities from both groups should inform future UK breast cancer surgical research, to ensure that it addresses questions that are important to breast cancer community as a whole.",

author = "Shelley Potter and Katherine Fairhurst and Katherine Cowan and Simon Vincent and Ian Lewis and Cutress, {Ramsey I} and Hilary Stobart and Patricia Fairbrother and Sophia Turner and Kayleigh Davies-Crowley and Ranjeet Jeevan and Tim Rattay and Rachel O'Connell and Nigel Bundred and McIntosh, {Stuart A}",

note = "Funding Information: This work was funded by the Association of Breast Surgery. Shelley Potter is an NIHR Clinician Scientist (CS-2016–16-019), Katherine Fairhurst and Tim Rattay are NIHR Clinical Lecturers. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health and Care Research or the Department of Health and Social Care. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

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Potter, S, Fairhurst, K, Cowan, K, Vincent, S, Lewis, I, Cutress, RI, Stobart, H, Fairbrother, P, Turner, S, Davies-Crowley, K, Jeevan, R, Rattay, T, O'Connell, R, Bundred, N & McIntosh, SA 2023, 'Identifying research priorities in breast cancer surgery: a UK priority setting partnership with the James Lind Alliance', Breast Cancer Research and Treatment, vol. 197, no. 1, pp. 39-49. https://doi.org/10.1007/s10549-022-06756-4

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T1 - Identifying research priorities in breast cancer surgery

T2 - a UK priority setting partnership with the James Lind Alliance

AU - Potter, Shelley

AU - Fairhurst, Katherine

AU - Cowan, Katherine

AU - Vincent, Simon

AU - Lewis, Ian

AU - Cutress, Ramsey I

AU - Stobart, Hilary

AU - Fairbrother, Patricia

AU - Turner, Sophia

AU - Davies-Crowley, Kayleigh

AU - Jeevan, Ranjeet

AU - Rattay, Tim

AU - O'Connell, Rachel

AU - Bundred, Nigel

AU - McIntosh, Stuart A

N1 - Funding Information: This work was funded by the Association of Breast Surgery. Shelley Potter is an NIHR Clinician Scientist (CS-2016–16-019), Katherine Fairhurst and Tim Rattay are NIHR Clinical Lecturers. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health and Care Research or the Department of Health and Social Care. Publisher Copyright: © 2022, The Author(s).

PY - 2023/1/1

Y1 - 2023/1/1

N2 - PURPOSE: A James Lind Alliance priority setting partnership was developed to identify research priorities in breast cancer surgery from individuals with lived experience, at high genetic risk of breast cancer, and healthcare professionals (HCPs).METHODS: 'Uncertainties' were collected using an online survey. Following an evidence check and development of summary questions, an interim survey asked participants to rank their top 10 research priorities from the question list. Top-ranked questions from patient/carer, high-risk and professional groups were carried forward for discussion to a final online prioritisation workshop.RESULTS: 260 participants (101 patients/carers, 156 HCPs) submitted 940 uncertainties via the initial survey. These were analysed thematically into 128 summary questions in six topic areas. Following evidence checking, 59 questions were included in the interim survey which was completed by 572 respondents. Marked differences were seen in questions prioritised by patients/carers, HCPs and women at high-risk. The top eight priorities in patient/carer and professional groups and top two priorities for high-risk women were carried forward to the online workshop at which 22 participants discussed and agreed the final top 10. Key themes included de-escalation of breast and axillary surgery, factors impacting the development/detection of locoregional recurrence and optimal provision of support for informed treatment decision-making.CONCLUSION: The top 10 research priorities in breast cancer surgery have been agreed. However, the observed differences in research priorities identified by patients and professional groups were not anticipated. Top priorities from both groups should inform future UK breast cancer surgical research, to ensure that it addresses questions that are important to breast cancer community as a whole.

AB - PURPOSE: A James Lind Alliance priority setting partnership was developed to identify research priorities in breast cancer surgery from individuals with lived experience, at high genetic risk of breast cancer, and healthcare professionals (HCPs).METHODS: 'Uncertainties' were collected using an online survey. Following an evidence check and development of summary questions, an interim survey asked participants to rank their top 10 research priorities from the question list. Top-ranked questions from patient/carer, high-risk and professional groups were carried forward for discussion to a final online prioritisation workshop.RESULTS: 260 participants (101 patients/carers, 156 HCPs) submitted 940 uncertainties via the initial survey. These were analysed thematically into 128 summary questions in six topic areas. Following evidence checking, 59 questions were included in the interim survey which was completed by 572 respondents. Marked differences were seen in questions prioritised by patients/carers, HCPs and women at high-risk. The top eight priorities in patient/carer and professional groups and top two priorities for high-risk women were carried forward to the online workshop at which 22 participants discussed and agreed the final top 10. Key themes included de-escalation of breast and axillary surgery, factors impacting the development/detection of locoregional recurrence and optimal provision of support for informed treatment decision-making.CONCLUSION: The top 10 research priorities in breast cancer surgery have been agreed. However, the observed differences in research priorities identified by patients and professional groups were not anticipated. Top priorities from both groups should inform future UK breast cancer surgical research, to ensure that it addresses questions that are important to breast cancer community as a whole.

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DO - 10.1007/s10549-022-06756-4

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JO - Breast Cancer Research and Treatment

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Identifying research priorities in breast cancer surgery: a UK priority setting partnership with the James Lind Alliance

Abstract

Bibliographical note

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Identifying research priorities for improving information and support for patients undergoing breast cancer surgery: a UK patient-centred priority setting project

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