IGFBP-2/PTEN: A critical interaction for tumours and for general physiology?

Li Zeng; Claire M Perks; Jeffrey M P Holly

doi:10.1016/j.ghir.2015.01.003

IGFBP-2/PTEN: A critical interaction for tumours and for general physiology?

Li Zeng, Claire M Perks, Jeffrey M P Holly

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18 Citations (Scopus)

Abstract

IGFBP-2 is an important modulator of IGF availability and activity. It is the second most abundant of the IGFBPs in the circulation and its levels are increased in a variety of tumours and associated with progression and poor prognosis. PTEN is a phosphatase that returns the PI3K/AKT/mTOR pathway to its inactivated state and is therefore a critical modulator of one of the main intracellular signalling pathways activated by the IGFs. Recent evidence has indicated that IGFBP-2 regulates PTEN in a variety of normal and malignant cell types. This review summarises the recent evidence that these extracellular and intracellular modulators are linked to provide a synchronous system for cell regulation with coordinated control of both the 'accelerator' and the 'brake'.

Original language	English
Pages (from-to)	103-7
Number of pages	5
Journal	Growth Hormone and IGF Research
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/j.ghir.2015.01.003
Publication status	Published - Jun 2015

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@article{e1661f8f43224b069b7d77a035d49d82,

title = "IGFBP-2/PTEN: A critical interaction for tumours and for general physiology?",

abstract = "IGFBP-2 is an important modulator of IGF availability and activity. It is the second most abundant of the IGFBPs in the circulation and its levels are increased in a variety of tumours and associated with progression and poor prognosis. PTEN is a phosphatase that returns the PI3K/AKT/mTOR pathway to its inactivated state and is therefore a critical modulator of one of the main intracellular signalling pathways activated by the IGFs. Recent evidence has indicated that IGFBP-2 regulates PTEN in a variety of normal and malignant cell types. This review summarises the recent evidence that these extracellular and intracellular modulators are linked to provide a synchronous system for cell regulation with coordinated control of both the 'accelerator' and the 'brake'.",

author = "Li Zeng and Perks, {Claire M} and Holly, {Jeffrey M P}",

year = "2015",

month = jun,

doi = "10.1016/j.ghir.2015.01.003",

language = "English",

volume = "25",

pages = "103--7",

journal = "Growth Hormone and IGF Research",

issn = "1096-6374",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - IGFBP-2/PTEN

T2 - A critical interaction for tumours and for general physiology?

AU - Zeng, Li

AU - Perks, Claire M

AU - Holly, Jeffrey M P

PY - 2015/6

Y1 - 2015/6

N2 - IGFBP-2 is an important modulator of IGF availability and activity. It is the second most abundant of the IGFBPs in the circulation and its levels are increased in a variety of tumours and associated with progression and poor prognosis. PTEN is a phosphatase that returns the PI3K/AKT/mTOR pathway to its inactivated state and is therefore a critical modulator of one of the main intracellular signalling pathways activated by the IGFs. Recent evidence has indicated that IGFBP-2 regulates PTEN in a variety of normal and malignant cell types. This review summarises the recent evidence that these extracellular and intracellular modulators are linked to provide a synchronous system for cell regulation with coordinated control of both the 'accelerator' and the 'brake'.

AB - IGFBP-2 is an important modulator of IGF availability and activity. It is the second most abundant of the IGFBPs in the circulation and its levels are increased in a variety of tumours and associated with progression and poor prognosis. PTEN is a phosphatase that returns the PI3K/AKT/mTOR pathway to its inactivated state and is therefore a critical modulator of one of the main intracellular signalling pathways activated by the IGFs. Recent evidence has indicated that IGFBP-2 regulates PTEN in a variety of normal and malignant cell types. This review summarises the recent evidence that these extracellular and intracellular modulators are linked to provide a synchronous system for cell regulation with coordinated control of both the 'accelerator' and the 'brake'.

U2 - 10.1016/j.ghir.2015.01.003

DO - 10.1016/j.ghir.2015.01.003

M3 - Article (Academic Journal)

C2 - 25683897

SN - 1096-6374

VL - 25

SP - 103

EP - 107

JO - Growth Hormone and IGF Research

JF - Growth Hormone and IGF Research

IS - 3

ER -

IGFBP-2/PTEN: A critical interaction for tumours and for general physiology?

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