IGFBP-2/PTEN: A critical interaction for tumours and for general physiology?

Li Zeng, Claire M Perks, Jeffrey M P Holly

Research output: Contribution to journalArticle (Academic Journal)peer-review

12 Citations (Scopus)

Abstract

IGFBP-2 is an important modulator of IGF availability and activity. It is the second most abundant of the IGFBPs in the circulation and its levels are increased in a variety of tumours and associated with progression and poor prognosis. PTEN is a phosphatase that returns the PI3K/AKT/mTOR pathway to its inactivated state and is therefore a critical modulator of one of the main intracellular signalling pathways activated by the IGFs. Recent evidence has indicated that IGFBP-2 regulates PTEN in a variety of normal and malignant cell types. This review summarises the recent evidence that these extracellular and intracellular modulators are linked to provide a synchronous system for cell regulation with coordinated control of both the 'accelerator' and the 'brake'.

Original languageEnglish
Pages (from-to)103-7
Number of pages5
JournalGrowth Hormone and IGF Research
Volume25
Issue number3
DOIs
Publication statusPublished - Jun 2015

Bibliographical note

Copyright © 2015 Elsevier Ltd. All rights reserved.

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