IL-6 microinjected in the nucleus tractus solitarii attenuates cardiac baroreceptor reflex function in rats

M Takagishi, H Waki, M E R Bhuiyan, S S Gouraud, A Kohsaka, H Cui, T Yamazaki, JFR Paton, M Maeda

Research output: Contribution to journalArticle (Academic Journal)peer-review

39 Citations (Scopus)

Abstract

Recent gene array and molecular studies have suggested that an abnormal gene expression profile of interleukin-6 (IL-6) in the nucleus tractus solitarii (NTS), a pivotal region for regulating arterial pressure, may be related to the development of neurogenic hypertension. However, the precise functional role of IL-6 in the NTS remains unknown. In the present study, we have tested whether IL-6 affects cardiovascular control at the level of the NTS. IL-6 (1, 10, and 100 fmol) was microinjected in the NTS of Wistar rats (280-350 g) under urethane anesthesia. Although the baseline levels of arterial pressure and heart rate did not change following IL-6 injections, the cardiac baroreflex in response to increased arterial pressure was dose-dependently attenuated. In addition, IL-6 (100 fmol) microinjections also attenuated l-glutamate-induced bradycardia at the level of the NTS. Immunohistochemical detection of IL-6 in naïve rats demonstrated that it was predominantly observed in neurons within the brain stem, including the NTS. These findings suggest that IL-6 within the NTS may play an important role for regulating cardiovascular control via modulation of input signals from baroreceptor afferents. Whether the abnormal gene expression of IL-6 in the NTS is associated in a causal way with hypertension remains to be resolved.
Translated title of the contributionIL-6 microinjected in the nucleus tractus solitarii attenuates cardiac baroreceptor reflex function in rats
Original languageEnglish
Pages (from-to)R183 - 90
Number of pages8
JournalAJP - Regulatory, Integrative and Comparative Physiology
Volume298
DOIs
Publication statusPublished - Jan 2010

Fingerprint Dive into the research topics of 'IL-6 microinjected in the nucleus tractus solitarii attenuates cardiac baroreceptor reflex function in rats'. Together they form a unique fingerprint.

Cite this