Imaging the placental glycocalyx with transmission electron microscopy

Anna Fabre-Gray, Colin Down, Chris Neal, Becky Foster, Simon Satchell, Victoria Bills

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)
67 Downloads (Pure)

Abstract

There is a significant glycocalyx present at the maternal-fetal interface of the human placenta, with increasing evidence to suggest it has an important role in placental function.

Glycocalyx is adversely affected by traditional tissue processing and fixation techniques. Using transmission electron microscopy, we present methodologies for reliably imaging and measuring glycocalyx of both the syncytiotrophoblast and fetal capillary endothelium in term healthy placentae.

These techniques can be used to study the role of the placental glycocalyx in both health and disease, in- cluding pre-eclampsia.
Original languageEnglish
Pages (from-to)59-61
Number of pages3
JournalPlacenta
Volume74
Early online date13 Dec 2018
DOIs
Publication statusPublished - 15 Dec 2018

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Keywords

  • Glycocalyx
  • pre-eclampsia
  • placenta
  • transmission electron microscopy

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