Abstract
There is a significant glycocalyx present at the maternal-fetal interface of the human placenta, with increasing evidence to suggest it has an important role in placental function.
Glycocalyx is adversely affected by traditional tissue processing and fixation techniques. Using transmission electron microscopy, we present methodologies for reliably imaging and measuring glycocalyx of both the syncytiotrophoblast and fetal capillary endothelium in term healthy placentae.
These techniques can be used to study the role of the placental glycocalyx in both health and disease, in- cluding pre-eclampsia.
Glycocalyx is adversely affected by traditional tissue processing and fixation techniques. Using transmission electron microscopy, we present methodologies for reliably imaging and measuring glycocalyx of both the syncytiotrophoblast and fetal capillary endothelium in term healthy placentae.
These techniques can be used to study the role of the placental glycocalyx in both health and disease, in- cluding pre-eclampsia.
| Original language | English |
|---|---|
| Pages (from-to) | 59-61 |
| Number of pages | 3 |
| Journal | Placenta |
| Volume | 74 |
| Early online date | 13 Dec 2018 |
| DOIs | |
| Publication status | Published - 15 Dec 2018 |
Keywords
- Glycocalyx
- pre-eclampsia
- placenta
- transmission electron microscopy
Access to Document
- Full-text PDF (accepted author manuscript)
This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at DOI: 10.1016/j.placenta.2018.12.004. Please refer to any applicable terms of use of the publisher.