Imidazolium labelling permits the sensitive mass-spectrometric detection of N-glycosides directly from serum

Yao-Yao Zhang, Mattia Ghirardello, Ting Wang, Ai-Min Lu, Li Liu, Josef Voglmeir, M Carmen Galan

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

A novel imidazolium derivative (GITag) shows superior ionisation and consequently allows increased mass spectrometric detection capabilities of oligosaccharides and N-glycans. Here we demonstrate that human serum samples can be directly labelled by GITag on a MALDI target plate, abrogating prevalently required sample pretreatment or clean-up steps.

Original languageEnglish
Pages (from-to)7003-7006
Number of pages4
JournalChemical communications (Cambridge, England)
Volume57
Issue number57
Early online date17 Jun 2021
DOIs
Publication statusPublished - 21 Jul 2021

Bibliographical note

Funding Information:
This study was funded by the National Natural Science Foundation of China (NSFC) 31471703, 31671854, 31871793 and 31871754 (to JV and LL), and ERC-COG: 648239 (MCG).

Publisher Copyright:
© The Royal Society of Chemistry 2021.

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