A novel imidazolium derivative (GITag) shows superior ionisation and consequently allows increased mass spectrometric detection capabilities of oligosaccharides and N-glycans. Here we demonstrate that human serum samples can be directly labelled by GITag on a MALDI target plate, abrogating prevalently required sample pretreatment or clean-up steps.
Bibliographical noteFunding Information:
This study was funded by the National Natural Science Foundation of China (NSFC) 31471703, 31671854, 31871793 and 31871754 (to JV and LL), and ERC-COG: 648239 (MCG).
© The Royal Society of Chemistry 2021.